Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives

Autor:	Yue Liu, Peng‐Xiao Li, Wen‐Wen Mu, Ya‐Lei Sun, Ren‐Min Liu, Jie Yang, Guo‐Yun Liu
Rok vydání:	2021
Předmět:	Bioengineering Antineoplastic Agents Apoptosis General Chemistry General Medicine Biochemistry Structure-Activity Relationship Cell Line Tumor Drug Design Barbiturates Molecular Medicine Drug Screening Assays Antitumor Molecular Biology Cell Proliferation
Zdroj:	Chemistrybiodiversity. 19(2)
ISSN:	1612-1880
Popis:	This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and acylation reaction. The cytotoxicity was assessed by the MTT assay. Flowcytometry was performed to determine the cell cycle arrest, apoptosis, ROS levels and the loss of MMP. The ratios of GSH/GSSG and the MDA levels were determined by using UV spectrophotometry. The results revealed that introducing substitutions (CF
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bec2c24b76490a42da4ecfbc11ed5c1 https://pubmed.ncbi.nlm.nih.gov/34931450 Zobrazit plný text záznamu Plný text