Abstinence from Cocaine and Sucrose Self-Administration Reveals Altered Mesocorticolimbic Circuit Connectivity by Resting State MRI
| Autor: | William P. Rea, Svetlana I. Chefer, Yihong Yang, D. Bruce Vaupel, Karine Guillem, Thomas J. Ross, Hanbing Lu, Laura L. Peoples, Qihong Zou, Elliot A. Stein |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Sucrose media_common.quotation_subject Drug-Seeking Behavior Hypothalamus Prefrontal Cortex Self Administration Nucleus accumbens Brain mapping Nucleus Accumbens Cocaine Recurrence medicine Animals Rats Long-Evans Prefrontal cortex media_common Brain Mapping Resting state fMRI medicine.diagnostic_test General Neuroscience Addiction Brain Original Articles Abstinence Magnetic Resonance Imaging Rats Nerve Net Hypoactivity Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Brain Connectivity. 4:499-510 |
| ISSN: | 2158-0022 2158-0014 |
| DOI: | 10.1089/brain.2014.0264 |
| Popis: | Previous preclinical studies have emphasized that drugs of abuse, through actions within and between mesocorticolimbic (MCL) regions, usurp learning and memory processes normally involved in the pursuit of natural rewards. To distinguish MCL circuit pathobiological neuroadaptations that accompany addiction from general learning processes associated with natural reward, we trained two groups of rats to self-administer either cocaine (IV) or sucrose (orally) followed by an identically enforced 30 day abstinence period. These procedures are known to induce behavioral changes and neuroadaptations. A third group of sedentary animals served as a negative control group for general handling effects. We examined low-frequency spontaneous fluctuations in the functional magnetic resonance imaging (fMRI) signal, known as resting-state functional connectivity (rsFC), as a measure of intrinsic neurobiological interactions between brain regions. Decreased rsFC was seen in the cocaine-SA compared with both sucrose-SA and housing control groups between prelimbic (PrL) cortex and entopeduncular nucleus and between nucleus accumbens core (AcbC) and dorsomedial prefrontal cortex (dmPFC). Moreover, individual differences in cocaine SA escalation predicted connectivity strength only in the Acb-dmPFC circuit. These data provide evidence of fronto-striatal plasticity across the addiction trajectory, which are consistent with Acb-PFC hypoactivity seen in abstinent human drug addicts, indicating potential circuit level biomarkers that may inform therapeutic interventions. They further suggest that available data from cross-sectional human studies may reflect the consequence of rather a predispositional predecessor to their dependence. |
| Databáze: | OpenAIRE |
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