SPIRAMYCIN IN THE PREVENTION OF POSTOPERATIVE STAPHYLOCOCCAL INFECTION
| Autor: | J.J. Robertson, J.A. Macfarlane, J.M. Walsh, A.A.B. Mitchell |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Staphylococcus Urinary system Antibiotics Erythromycin medicine.disease_cause Leucomycins Macrolide Antibiotics Sepsis Internal medicine Preoperative Care medicine Humans Surgical Wound Infection Aged Postoperative Care Prostatectomy business.industry Genitourinary system Spiramycin Prostate Drug Resistance Microbial General Medicine Middle Aged Staphylococcal Infections biochemical phenomena metabolism and nutrition medicine.disease Surgery Staphylococcus aureus business medicine.drug |
| Zdroj: | The Lancet. 291:1-4 |
| ISSN: | 0140-6736 |
| Popis: | The antibiotic spiramycin (' Rovamycin ') was given prophylactically to all patients undergoing prostatectomy during 1965 and 1966, from their day of admission to hospital until the tenth postoperative day. There was a general reduction in staphylococcal wound and pulmonary sepsis from 11 out of 70 patients (15.7%) in 1964 to 1 out of 101 patients (0.9%) in 1965. In 1966 the figure rose to 4 out of 88 (4.4%), but in both 1965 and 1966 there was no postoperative staphylococcal wound sepsis. Serum and prostate levels of spiramycin were measured, and it is suggested that it is the persistence and concentration of the antibiotic in the tissues which may be responsible for the reduction in sepsis. Of 1544 strains of Staphylococcus aureus isolated, 308 were resistant to erythromycin, but only 13 were resistant to spiramycin. No spiramycin-resistant strains were isolated in the genitourinary unit during 1965, and of 4 isolated from there in 1966, only 1 was from a patient who had received the antibiotic. Side-effects were noted in only one patient who had a drug rash after fourteen days treatment; this necessitated withdrawal of spiramycin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|