Cytokines concentrations in aqueous humor of eyes with uveal melanoma
| Autor: | Jianhong Liang, Xuemei Zhu, Jing Feng, Yong Cheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Uveal Neoplasms Vascular Endothelial Growth Factor A genetic structures Chemotactic Cytokines Observational Study Aqueous humor Cataract Extraction Malignancy Cataract extraction Aqueous Humor 03 medical and health sciences 0302 clinical medicine medicine Biomarkers Tumor Humans 030212 general & internal medicine Melanoma Aged Epidermal Growth Factor business.industry General Medicine Middle Aged medicine.disease eye diseases cytokines 030220 oncology & carcinogenesis Cancer research Female sense organs uveal melanoma Inflammation Mediators business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Uveal melanoma (UM) is the major intraocular malignancy in adults, of which the molecular biology is still unknown. Therefore, this study was designed to determine the aqueous concentrations of angiogenic, inflammatory, and chemotactic cytokines in eyes with UM. Aqueous humor samples were collected from 38 patients with UM and 22 patients undergoing cataract surgery. Interleukin 6, 8 (IL-6, IL-8, respectively), interferon-inducible protein-10 (IP-10), placental growth factor1 (PIGF1), regulated on activation, normal T Cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1), nerve growth factor-beta (NGF-β), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and vascular endothelia growth factor A (VEGF-A) were assessed by multiplex bead assay. In the study group, significantly higher concentrations of IL-6 (P = .006), IL-8 (P = .018), IP-10 (P = .004), RANTES (P = .008), MCP-1 (P = .02), NGF-β (P = .013), EGF (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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