Residential greenness and birth outcomes: Evaluating the mediation and interaction effects of particulate air pollution

Autor: Chi Yen Hung, Pei-Chen Lee, Chia Kai Wu, Chih Da Wu, Hui Ju Tsai, Sheng-Hsuan Lin, Hsin Yun Tsai, Tsung Chieh Yao
Rok vydání: 2021
Předmět:
Adult
Mediation (statistics)
Health
Toxicology and Mutagenesis
Birth weight
Taiwan
0211 other engineering and technologies
02 engineering and technology
010501 environmental sciences
Interaction
01 natural sciences
Environmental pollution
Pregnancy
Air Pollution
Linear regression
Birth outcomes
Humans
Medicine
Particulate matter air pollution
GE1-350
Retrospective Studies
0105 earth and related environmental sciences
Air Pollutants
021110 strategic
defence & security studies
business.industry
Infant
Newborn
Pregnancy Outcome
Public Health
Environmental and Occupational Health
Retrospective cohort study
General Medicine
Infant
Low Birth Weight
medicine.disease
Pollution
Mediation effect
Environmental sciences
Low birth weight
TD172-193.5
Maternal Exposure
Greenness
Premature Birth
Small for gestational age
Female
Particulate Matter
Interaction effect
medicine.symptom
business
Demography
Zdroj: Ecotoxicology and Environmental Safety, Vol 211, Iss, Pp 111915-(2021)
ISSN: 0147-6513
DOI: 10.1016/j.ecoenv.2021.111915
Popis: Background The few studies that examined the association between residential greenness and birth outcomes have produced inconsistent results, and the underlying mechanisms of these associations remain unclear. Objectives We examined the mediation and interaction effects of particulate matter (PM) air pollution on the relationship between greenness exposure during the first and third trimesters of pregnancy and birth outcomes, including preterm birth (PTB), term low birth weight (TLBW), small for gestational age (SGA), birth weight (BW), and head circumference (HC). Methods We conducted a retrospective cohort study on 16,184 singleton live births between 2010 and 2012 in Taiwan. Residential greenness was estimated based on the normalized difference vegetation index (NDVI), and the PM information during the first and third trimesters was estimated through hybrid kriging land use regression and ordinary kriging interpolation methods. Multiple regression analyses were performed to evaluate the associations between greenness exposure and birth outcomes. We estimated the mediating effects of PM associated with greenness exposure on birth outcomes through causal mediation analyses. We also examined the potential multiplicative and additive interactions between greenness exposure and PM and their effects on birth outcomes. Results The first trimester NDVI exposure was associated with reduced risks for PTB, TLBW, and SGA, which had an adjusted OR (aOR) of 0.93 (95% CI: 0.89–0.97), 0.91 (95% CI: 0.83–0.99), and 0.95 (95% CI: 0.91–1.00), respectively, per 0.1 unit increase in multi-pollutant models. The causal mediation analysis showed that PM mediated approximately 5–19% of the association between first and third trimester greenness and PTB and mediated approximately 15–37% of the association between greenness and SGA. We identified multiplicative interactions in log scale between first trimester PM10 and NDVI exposure for SGA (aORinteraction = 0.92, p = 0.03) and HC (estimateinteraction = 1.47, p = 0.04). Conclusions This study revealed beneficial associations between residential greenness and birth outcomes, including PTB, TLBW, and SGA. The associations were partly mediated by a reduction in exposure to PM air pollution. Summary The beneficial effects of greenness on PTB and SGA are partly mediated by a reduction in exposure to PM air pollution.
Databáze: OpenAIRE
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