Expression of angiotensin II AT2 receptor mRNA during development of rat kidney and adrenal gland
| Autor: | Eric Clauser, Pierre Corvol, Sadoutounissa Shanmugam, Catherine Llorens-Cortes, J.-M. Gasc |
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| Rok vydání: | 1995 |
| Předmět: |
Aging
endocrine system medicine.medical_specialty Physiology medicine.medical_treatment Biology Kidney Rats Sprague-Dawley Embryonic and Fetal Development Fetus Internal medicine Adrenal Glands Renin–angiotensin system medicine Animals RNA Messenger Receptor Receptors Angiotensin Angiotensin II receptor type 1 urogenital system Adrenal gland Growth factor Angiotensin II Rats medicine.anatomical_structure Endocrinology Animals Newborn cardiovascular system hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology Endocrine gland |
| Zdroj: | American Journal of Physiology-Renal Physiology. 268:F922-F930 |
| ISSN: | 1522-1466 1931-857X |
| Popis: | The angiotensin II (ANG II) receptors have been pharmacologically classified into two major distinct types, designated AT1 and AT2. A high transient expression of AT2 receptors in the fetal tissues has been previously demonstrated. This study describes the cellular distribution of AT2 receptor mRNA in the developing rat kidney and adrenal gland by in situ hybridization with 35S-labeled cRNA probes. From day 12 of fetal life (F12) to day 15 postpartum (D15) AT2 mRNA was detected in the undifferentiated nephrogenic mesenchymal tissue but not in the immature and mature glomeruli and tubules of the kidney. No AT2 mRNA was observed in the kidney after D22. The adrenal gland also expressed AT2 receptor mRNA early during development from F12 but, unlike the kidney, continuously expressed the mRNA at high levels through to adulthood. The disappearance of AT2 mRNA in the kidney was synchronous with the completion of nephrogenesis and suggests that ANG II might act through this receptor as a differentiation/growth factor during nephron development. In the adrenal gland ANG II could act as a hormone and also as a differentiation/growth factor via the AT2 receptor. |
| Databáze: | OpenAIRE |
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