Photocatalytic Generation of π‐Allyltitanium Complexes via Radical Intermediates

Autor:	Fusheng Li, Huaipu Yan, Lei Shi, Shuangjie Lin, Yuqing Chen, Caizhe Shi, Chunying Duan, Luqing Lin, Chao Wu, Chenchen Li
Rok vydání:	2020
Předmět:	010405 organic chemistry Radical 1 3-Butadiene chemistry.chemical_element General Medicine General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Rapid access Photocatalysis Titanium
Zdroj:	Angewandte Chemie International Edition. 60:1561-1566
ISSN:	1521-3773 1433-7851
DOI:	10.1002/anie.202010780
Popis:	The addition of π-allylmetal complexes to carbonyls is the most important route to homoallylic alcohols. This study reports the first photocatalytic generation of π-allyltitanium complexes by a radical strategy. This novel strategy enables the three-component allylation of carbonyls with 1,3-butadiene, providing rapid access to valuable homoallylic alcohols (over 60 examples). The exceptional regio- and diastereoselectivity provided by dual photoredox/Ti catalysis is comparable to that of the Cr-catalyzed Nozaki-Hiyama-Kishi allylation reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be07e1d11ca971907a2a701a2648a1f https://doi.org/10.1002/anie.202010780 Zobrazit plný text záznamu Plný text