Exposure to selected endocrine disruptors and neonatal outcome of 86 healthy boys from Nice area (France)
| Autor: | André Bongain, Isabelle Delattre, Pierre Azuar, Jocelyn Gal, Patricia Pacini, Patrick Fénichel, Kathy Wagner-Mahler, Françoise Brucker-Davis, Laure Bornebusch, Camille Tommasi, Mireille Boda-Buccino, Patricia Ferrari |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Environmental Engineering Health Toxicology and Mutagenesis Birth weight Endocrine Disruptors Xenobiotics chemistry.chemical_compound Internal medicine Lactation medicine Environmental Chemistry Endocrine system Birth Weight Humans Fetus Milk Human Chemistry Public Health Environmental and Occupational Health Infant Newborn food and beverages Gestational age General Medicine General Chemistry Hexachlorobenzene Environmental Exposure Fetal Blood Pollution medicine.anatomical_structure Endocrinology Endocrine disruptor In utero Female France Environmental Monitoring |
| Zdroj: | Chemosphere. 81(2) |
| ISSN: | 1879-1298 |
| Popis: | In utero and lactational exposure to endocrine disruptors is thought to be potentially harmful on fetal and infant development. Data of exposure in France is scarce. This is a prospective study with (1) collection of 84 cord bloods (CB) and 69 milks from 86 mothers delivering healthy boys (gestational age >or= 34 weeks) at two maternity wards in Southern France, between 2002 and 2005 and (2) screening for 15 xenobiotics with anti-androgenic and/or estrogenic effects: DDE, 7 PCBs, dibutylphthalate and its metabolite mBP, HCB, lindane, linuron, procymidone and vinclozoline. Correlations were made with delivery and neonatal outcomes. All CB and milks were contaminated by one or more xenobiotics (mainly PCBs, DDE, HCB, and phthalates) with good correlation between CB and milk concentrations. Compared to other geographical areas, exposure was usually in the lower bracket. Milk [PCB180] was associated with lower birth weight. Infant head circumference correlated negatively with [HCB] and positively with [mBP] in CB. There was a similar but not significant trend for birth weight and length. [DDE] in milk was higher in older mothers and in women born in Africa. In utero and lactational exposure is ubiquitous in our area. Contamination of milk with HCB, mBP, and PCB 180 showed weak correlations with infant growth. This snapshot of exposure in an area with no major industry will serve for further monitoring. |
| Databáze: | OpenAIRE |
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