POTENTIATION OF AMP-AMINOHYDROLASE ACTIVITY OF BRAIN MITOCHONDRIA BY HEXOKINASE
| Autor: | A. V. Haroutunian, H. Ch. Buniatian |
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| Rok vydání: | 1971 |
| Předmět: |
Time Factors
Biochemical Phenomena Centrifugation Brain mitochondria Biology Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Adenosine Triphosphate Aminohydrolases Ammonia Hexokinase Yeasts Animals AMP aminohydrolase activity Microscopy Phase-Contrast chemistry.chemical_classification Adenine Nucleotides Brain Long-term potentiation Adenosine Monophosphate Yeast Mitochondria Rats Enzyme Activation Molecular Weight Enzyme chemistry Deamination Spectrophotometry NADP |
| Zdroj: | Journal of Neurochemistry. 18:859-867 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1971.tb12016.x |
| Popis: | — The addition of hexokinase (yeast and brain) to mitochondrial fractions of brain (rat) resulted in a considerable increase of formation of ammonia from AMP. The mechanisms underlying the activation of AMP-aminohydrolase of brain mitochondria by ATP and hexokinase are quite different. In the activation of AMP-aminohydrolase by hexokinase the SH-groups of both enzymes particularly of the latter are of importance. Brain mitochondria contain low-molecular dialysable substances of unknown nature which are necessary for the interaction of both enzymes. |
| Databáze: | OpenAIRE |
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