Involvement of brainstem noradrenergic system in cutaneous heat loss during exercise
| Autor: | Gisele Vieira Rodovalho, Candido Celso Coimbra, Lucas Rios Drummond |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adrenergic Neurons Male medicine.medical_specialty Tyrosine 3-Monooxygenase Period (gene) Vasodilation 03 medical and health sciences Norepinephrine 0302 clinical medicine Internal medicine Physical Conditioning Animal medicine Animals Rats Wistar Tyrosine hydroxylase Chemistry General Neuroscience Thermoregulation Rats Preoptic area 030104 developmental biology Endocrinology Locus coeruleus Brainstem medicine.symptom Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery Vasoconstriction Body Temperature Regulation Brain Stem |
| Zdroj: | Brain research bulletin. 164 |
| ISSN: | 1873-2747 |
| Popis: | The involvement of brainstem noradrenergic system in thermoregulation during exercise was evaluated by assessing the neuronal activation of A1, A2, locus coeruleus (LC) during exercise. Male Wistar rats weighing 280−330 g were used in the present study. Ninety minutes after exercise bout until fatigue, animals were anaesthesiated and brain removed and processed immunohistochemically for Fos protein and tyrosine hydroxylase in A1, A2 and LC and for Fos in POA subregions. Core and tail temperature were recorded during all running period by telemetry system. Heat storage rate (HSR, cal.min−1), maximum tail vasoconstriction (°C) and vasodilatation threshold (°C) were calculated and correlated with Fos expression in all nuclei studied. Fos expression in LC correlated inversely with maximum tail skin vasoconstriction (r = −0.787, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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