Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice
Autor: | Janet K. Jansson, Michael Hang, Susan E. Celniker, Yurong Huang, James B. Brown, Sasha A. Langley, Antoine M. Snijders, Kristofer E. Bouchard, Gary H. Karpen, Jian-Hua Mao |
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Rok vydání: | 2015 |
Předmět: |
Genotype
Genetic Linkage Quantitative Trait Loci Inbred Strains Mice Inbred Strains Motor Activity Quantitative trait locus Biology Article Mice 03 medical and health sciences 0302 clinical medicine Inbred strain Risk Factors Genetic linkage Genetics medicine Animals Humans 2.1 Biological and endogenous factors Obesity Aetiology Behavioural genetics Nutrition 030304 developmental biology 0303 health sciences Multidisciplinary Prevention Body Weight Human Genome Neurosciences Chromosome Mapping medicine.disease Phenotype Other Physical Sciences Cohort Biochemistry and Cell Biology 030217 neurology & neurosurgery |
Zdroj: | Mao, JH; Langley, SA; Huang, Y; Hang, M; Bouchard, KE; Celniker, SE; et al.(2015). Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice. Scientific Reports, 5. doi: 10.1038/srep16247. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/57c6r2cr Scientific reports, vol 5, iss 1 Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. Here we used the Collaborative Cross (CC), a large panel of newly inbred mice that captures 90% of the known variation among laboratory mice, to identify the genetic loci controlling rotarod performance and its relationship with body weight in a cohort of 365 mice across 16 CC strains. Body weight and rotarod performance varied widely across CC strains and were significantly negatively correlated. Genetic linkage analysis identified 14 loci that were associated with body weight. However, 45 loci affected rotarod performance, seven of which were also associated with body weight, suggesting a strong link at the genetic level. Lastly, we show that genes identified in this study overlap significantly with those related to neurological disorders and obesity found in human GWA studies. In conclusion, our results provide a genetic framework for studies of the connection between body weight, the central nervous system and behavior. |
Databáze: | OpenAIRE |
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