Determination of dimethindene in human tears by high-performance liquid chromatography
| Autor: | Georges Anderegg, Valdo Arnera, Philippe Bibas, René Lanz, Daniel F. Chollet |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Chromatography
Dimethindene Chemistry Irreversible adsorption Analytical chemistry Reproducibility of Results General Chemistry Reference Standards High-performance liquid chromatography Biological fluid chemistry.chemical_compound Dimetindene Tears Anti-Allergic Agents Calibration Humans Quantitative analysis (chemistry) Chromatography High Pressure Liquid |
| Zdroj: | Journal of chromatography. B, Biomedical sciences and applications. 707(1-2) |
| ISSN: | 1387-2273 |
| Popis: | A high-performance liquid chromatographic method is described for the determination of dimethindene in human tears. The tear samples were diluted in a 0.01 M hydrochloric acid-n-propanol mixture to prevent the irreversible adsorption of dimethindene. The diluted samples were directly injected into the chromatographic system to avoid sample pretreatment. The validation data demonstrate that the method is specific, precise and accurate within the calibration range of 12 to 1000 ng/ml dimethindene free base. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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