Effects of exercise training and montelukast in children with mild asthma
Autor: | Maria R. Bonsignore, Anna Bonanno, Marco Virzi, Amelia Interrante, Mirella Profita, Veca M, Margherita Marchese, Giuseppe Morici, Stefania La Grutta, Giuseppina Cuttitta, Fabio Cibella, Nicola Scichilone |
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Přispěvatelé: | BONSIGNORE, MR, LA GRUTTA, S, CIBELLA, F, SCICHILONE, N, CUTTITTA, G, INTERRANTE, A, MARCHESE M, VECA, M, VIRZI, M, BONANNO, A, PROFITA, M, MORICI, G |
Jazyk: | angličtina |
Rok vydání: | 2008 |
Předmět: |
Cyclopropanes
Male Quinoline Acetates Settore BIO/09 - Fisiologia immune system diseases Medicine Orthopedics and Sports Medicine Anti-Asthmatic Agents Child Methacholine Chloride Leukotriene education.field_of_study respiratory system Exercise Therapy Asthma Exercise-Induced Breath Tests Italy Exhalation Anesthesia Quinolines Female medicine.drug Human medicine.medical_specialty Breath Test Bronchoconstriction Population Physical Therapy Sports Therapy and Rehabilitation Physical exercise Sulfides Settore MED/10 - Malattie Dell'Apparato Respiratorio Internal medicine Aerobic exercise Humans Anti-Asthmatic Agent education Montelukast Asthma business.industry Leukotriene receptor Acetate Bronchospirometry medicine.disease respiratory tract diseases Physical Fitness Physical Fitne Exercise Test Methacholine business |
Popis: | Data from the general population suggest that habitual exercise decreases bronchial responsiveness, but the possible role of exercise in asthmatics is undefined. The leukotriene receptor antagonist montelukast decreases bronchial responsiveness and exercise-induced symptoms in asthmatic children. This randomized study in children with mild asthma evaluated the combined effects of aerobic training for 12 wk and montelukast or placebo on bronchial responsiveness (BHR) to methacholine, exercise-induced bronchoconstriction (EIB), inflammatory markers in exhaled breath condensate (EBC), and asthma exacerbations.Fifty children (mean age +/- SD: 10.2 +/- 2.4 yr) with mild stable asthma were randomly assigned to placebo (N = 25) or montelukast (N = 25). Before and after training, we assessed BHR and EIB and markers of airway inflammation-that is, exhaled nitric oxide (eNO), pH, and cysteinyl-leukotriene concentration-in EBC.Training increased maximal workload and peak minute ventilation. After training, the methacholine dose causing a 20% fall in FEV1 (PD20) increased in both groups. A decreased slope of FEV1 decline at increasing methacholine dose was found only in montelukast-treated children. EIB prevalence halved after training in both groups (EIB + children, placebo group: 10 pretraining, 4 posttraining; EIB + children, montelukast group: 8 pretraining, 5 posttraining; P0.05 by chi on all children). Resting eNO was unaffected, whereas the pH of EBC decreased after training in both groups. Cysteinyl-leukotriene concentrations were low in most children at both times. During training, montelukast-treated children showed fewer asthma exacerbations compared with the same period of the previous year.In children with mild stable asthma, exercise training decreased bronchial responsiveness to methacholine. Montelukast also decreased bronchial reactivity (FEV1 slope) and protected against exacerbations, suggesting a beneficial synergistic action of these two interventions in mild asthma. |
Databáze: | OpenAIRE |
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