Effects of exercise training and montelukast in children with mild asthma

Autor: Maria R. Bonsignore, Anna Bonanno, Marco Virzi, Amelia Interrante, Mirella Profita, Veca M, Margherita Marchese, Giuseppe Morici, Stefania La Grutta, Giuseppina Cuttitta, Fabio Cibella, Nicola Scichilone
Přispěvatelé: BONSIGNORE, MR, LA GRUTTA, S, CIBELLA, F, SCICHILONE, N, CUTTITTA, G, INTERRANTE, A, MARCHESE M, VECA, M, VIRZI, M, BONANNO, A, PROFITA, M, MORICI, G
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Cyclopropanes
Male
Quinoline
Acetates
Settore BIO/09 - Fisiologia
immune system diseases
Medicine
Orthopedics and Sports Medicine
Anti-Asthmatic Agents
Child
Methacholine Chloride
Leukotriene
education.field_of_study
respiratory system
Exercise Therapy
Asthma
Exercise-Induced

Breath Tests
Italy
Exhalation
Anesthesia
Quinolines
Female
medicine.drug
Human
medicine.medical_specialty
Breath Test
Bronchoconstriction
Population
Physical Therapy
Sports Therapy and Rehabilitation

Physical exercise
Sulfides
Settore MED/10 - Malattie Dell'Apparato Respiratorio
Internal medicine
Aerobic exercise
Humans
Anti-Asthmatic Agent
education
Montelukast
Asthma
business.industry
Leukotriene receptor
Acetate
Bronchospirometry
medicine.disease
respiratory tract diseases
Physical Fitness
Physical Fitne
Exercise Test
Methacholine
business
Popis: Data from the general population suggest that habitual exercise decreases bronchial responsiveness, but the possible role of exercise in asthmatics is undefined. The leukotriene receptor antagonist montelukast decreases bronchial responsiveness and exercise-induced symptoms in asthmatic children. This randomized study in children with mild asthma evaluated the combined effects of aerobic training for 12 wk and montelukast or placebo on bronchial responsiveness (BHR) to methacholine, exercise-induced bronchoconstriction (EIB), inflammatory markers in exhaled breath condensate (EBC), and asthma exacerbations.Fifty children (mean age +/- SD: 10.2 +/- 2.4 yr) with mild stable asthma were randomly assigned to placebo (N = 25) or montelukast (N = 25). Before and after training, we assessed BHR and EIB and markers of airway inflammation-that is, exhaled nitric oxide (eNO), pH, and cysteinyl-leukotriene concentration-in EBC.Training increased maximal workload and peak minute ventilation. After training, the methacholine dose causing a 20% fall in FEV1 (PD20) increased in both groups. A decreased slope of FEV1 decline at increasing methacholine dose was found only in montelukast-treated children. EIB prevalence halved after training in both groups (EIB + children, placebo group: 10 pretraining, 4 posttraining; EIB + children, montelukast group: 8 pretraining, 5 posttraining; P0.05 by chi on all children). Resting eNO was unaffected, whereas the pH of EBC decreased after training in both groups. Cysteinyl-leukotriene concentrations were low in most children at both times. During training, montelukast-treated children showed fewer asthma exacerbations compared with the same period of the previous year.In children with mild stable asthma, exercise training decreased bronchial responsiveness to methacholine. Montelukast also decreased bronchial reactivity (FEV1 slope) and protected against exacerbations, suggesting a beneficial synergistic action of these two interventions in mild asthma.
Databáze: OpenAIRE