Hypoalbuminemia with valproic acid administration
| Autor: | Yvette M. Janvier, Janice M Baunach, Carol A Bilat, Thomas A Rugino |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Divalproex medicine.medical_specialty medicine.medical_treatment Population Serum albumin Developmental Neuroscience Seizures Internal medicine medicine Humans Hypoalbuminemia Child education Serum Albumin education.field_of_study Valproic Acid medicine.diagnostic_test biology business.industry Albumin medicine.disease Endocrinology Anticonvulsant Neurology Child Preschool Pediatrics Perinatology and Child Health biology.protein Anticonvulsants Female Neurology (clinical) Liver function tests business medicine.drug |
| Zdroj: | Pediatric Neurology. 29:440-444 |
| ISSN: | 0887-8994 |
| DOI: | 10.1016/s0887-8994(03)00310-2 |
| Popis: | Valproic acid and its derivatives are commonly administered antiepileptic drugs for children and adults. Five residents at a children's long-term care facility manifested hypoalbuminemia while being administered divalproex, although serum liver function test results and urinalysis results were normal. When the patients were free from valproic acid, the serum albumin levels increased into the normal range (17-30% higher than the serum albumin levels while patients were receiving valproic acid) despite the absence of any dietary changes. Comparing the serum albumin levels for eight residents who received divalproex (3.1 gm/dL +/- 0.4 gm/dL) with the serum albumin levels for 13 residents who were not receiving valproic acid or its derivatives (3.8 gm/dL +/- 0.2 gm/dL), the difference was significant (P0.001). This difference could not be accounted for by nutritional, environmental, laboratory, or urinary causes. In this study, divalproex administration was a contributing factor in the development of reversible hypoalbuminemia in this population of severely disabled, neurologically injured children and young adults. Further studies are required to determine the exact etiology and clinical significance of valproate-mediated hypoalbuminemia. |
| Databáze: | OpenAIRE |
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