Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb
| Autor: | Jean-Christophe Olivo-Marin, Pierre-Marie Lledo, Armen Saghatelyan, Morgane Lemasson |
|---|---|
| Přispěvatelé: | Perception et Mémoire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Analyse d'Images Quantitative, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2005 |
| Předmět: |
Male
MESH: Olfactory Bulb Programmed cell death Development/Plasticity/Repair Population MESH: Neurons Apoptosis Olfaction Biology MESH: Animals Newborn Mouse Olfactory Bulb Mice 03 medical and health sciences 0302 clinical medicine Cell Movement Interneurons MESH: Mice Inbred C57BL medicine Animals MESH: Animals education MESH: Cell Movement MESH: Mice 030304 developmental biology Postnatal brain Neurons MESH: Age Factors 0303 health sciences education.field_of_study MESH: Apoptosis General Neuroscience Neurogenesis Age Factors Olfactory Pathways Granule cell Olfactory Bulb MESH: Interneurons MESH: Male Olfactory bulb Mice Inbred C57BL medicine.anatomical_structure Animals Newborn MESH: Cell Division [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neuroscience Cell Division MESH: Olfactory Pathways 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2005, 25 (29), pp.6816-25. ⟨10.1523/JNEUROSCI.1114-05.2005⟩ Journal of Neuroscience, 2005, 25 (29), pp.6816-25. ⟨10.1523/JNEUROSCI.1114-05.2005⟩ |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.1114-05.2005 |
| Popis: | International audience; In mammals, the olfactory bulb (OB) constitutes one of two regions of the postnatal brain with continuous neurogenesis throughout life. Despite intense explorations of neuronal replacement in the adult OB, little is known about the mechanisms that operate at earlier postnatal stages. This question is particularly pertinent, because the majority of local interneurons are born in the neonate, when olfaction controls vital functions. Here, we analyzed the recruitment of newborn cells to the granule cell (GC) layer (GCL) and found that the postnatal mouse OB is supplied with two spatiotemporally distinct populations of newborn interneurons. Early born [postnatal day 3 (P3) to P7] GCs constitute a threefold larger population compared with those generated later (P14-P60), and some of them are produced locally within the OB itself. Newborn interneurons generated at P3-P7 were predominantly targeted to the external edge of the GCL, whereas newly generated cells were positioned deeper in older mice. Additionally, although approximately 50% of adult newborn cells were eliminated within a few weeks of reaching the OB, almost the entire population of early born GCs survived until adulthood. Importantly, early olfactory experience specifically modifies the number of newborn GCs in neonates but leaves unaltered the amount of neurons generated during adulthood. Together, these results demonstrate that early postnatal neurogenesis endows the neonate bulbar circuit with newborn GCs that differ morphologically and functionally from those produced in the adult. |
| Databáze: | OpenAIRE |
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