Intravascular hemolytic anemia in a patient with antibodies related to meropenem
| Autor: | Hiroshi Shiragami, Masaharu Nohgawa, Satoko Oka |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Hemolytic anemia
medicine.medical_specialty Anemia Hemolytic Anemia Meropenem Antibodies Serology Immune Hemolytic Anemia Coombs test Internal Medicine medicine Humans Serologic Tests Intensive care medicine Aged medicine.diagnostic_test biology business.industry General Medicine medicine.disease Hemolysis Coombs Test Immunology biology.protein Female Thienamycins Antibody business medicine.drug |
| Zdroj: | Internal medicine (Tokyo, Japan). 54(10) |
| ISSN: | 1349-7235 |
| Popis: | A 76-year-old woman treated with meropenem developed intravascular hemolytic attacks. A direct antiglobulin test was positive for C3d and IgG, and drug-dependent antibody testing indicated that the antibodies were indeed drug-dependent and reacted with drug-treated RBCs and RBCs in the presence of the drug. To our knowledge, this is the first reported case in which the causative antibodies related to meropenem were identified. This case highlights the importance of maintaining a high level of suspicion for drug-induced immune hemolytic anemia in patients with explained hemolysis as well as conducting specialized serologic testing. |
| Databáze: | OpenAIRE |
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