Falls in Spinocerebellar Ataxias: Results of the EuroSCA Fall Study
| Autor: | Berry Kremer, C.C.P. Verstappen, Paola Giunti, Thomas Klockgether, Lisa Bunn, Dagmar Timmann, Massimo Pandolfo, T. Schmitz-Hübsch, Anna De Rosa, Perrine Charles, C. Globas, Bart P.C. van de Warrenburg, Alexandra Durr, Béla Melegh, Allesandro Filla, Ella M. R. Fonteyn, Bastiaan R. Bloem, Silvia Boesch, Laslo Baliko, Marten Munneke, Ludger Schöls |
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| Přispěvatelé: | Internal Medicine Specializations, University of Zurich, Fonteyn, Em, Schmitz Hübsch, T, Verstappen, Cc, Baliko, L, Bloem, Br, Boesch, S, Bunn, L, Charles, P, Dürr, A, Filla, Alessandro, Giunti, P, Globas, C, Klockgether, T, Melegh, B, Pandolfo, M, DE ROSA, Anna, Schöls, L, Timmann, D, Munneke, M, Kremer, Bp, van de Warrenburg, Bp |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Ataxia Genotype Quality of nursing and allied health care [NCEBP 6] Medizin Poison control 610 Medicine & health FEAR Extrapyramidal symptoms Surveys and Questionnaires Injury prevention Medicine Humans Spinocerebellar Ataxias Longitudinal Studies Aged Dystonia business.industry ataxia Middle Aged medicine.disease SCA 10040 Clinic for Neurology PREVALENCE Europe Pyramidal Logistic Models 2728 Neurology (clinical) Neurology 2808 Neurology Spinocerebellar ataxia Physical therapy Etiology RISK-FACTORS Female Falls INJURIES Neurology (clinical) medicine.symptom business Functional Neurogenomics [DCN 2] Natural history study |
| Zdroj: | ResearcherID Cerebellum, 9, 2, pp. 232-9 Cerebellum, 9, 232-9 Cerebellum, 9(2), 232-239. SPRINGER |
| ISSN: | 1473-4222 |
| Popis: | Contains fulltext : 88635.pdf (Publisher’s version ) (Closed access) To investigate the frequency, details, and consequences of falls in patients with autosomal dominant spinocerebellar ataxias (SCAs) and to derive specific disease-related risk factors that are associated with an increased fall frequency. Two hundred twenty-eight patients with SCA1, SCA2, SCA3, or SCA6, recruited from the EuroSCA natural history study, completed a fall questionnaire that assessed the frequency, consequences, and several details of falls in the previous 12 months. Relevant disease characteristics were retrieved from the EuroSCA registry. The database of the natural history study provided the ataxia severity scores as well as the number and nature of non-ataxia symptoms. Patients (73.6%) reported at least one fall in the preceding 12 months. There was a high rate of fall-related injuries (74%). Factors that were associated with a higher fall frequency included: disease duration, severity of ataxia, the presence of pyramidal symptoms, the total number of non-ataxia symptoms, and the genotype SCA3. Factors associated with a lower fall frequency were: the presence of extrapyramidal symptoms (more specifically dystonia of the lower limbs) and the genotype SCA2. The total number of non-ataxia symptoms and longer disease duration were independently associated with a higher fall frequency in a logistic regression analysis, while the presence of extrapyramidal symptoms was independently associated with a lower fall frequency. Our findings indicate that, in addition to more obvious factors that are associated with frequent falls, such as disease duration and ataxia severity, non-ataxia manifestations in SCA play a major role in the fall etiology of these patients. 01 juni 2010 |
| Databáze: | OpenAIRE |
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