Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy
| Autor: | Dong-Wook Han, Woo Yeup Jeong, Moon Sung Kang, So Yun Lee, Ki Su Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Theranostic Nanomedicine Biocompatibility receptors 02 engineering and technology Review 010402 general chemistry 01 natural sciences lcsh:RC254-282 theranosis chemistry.chemical_compound Hyaluronic acid hyaluronic acid medicine Liposome Chemistry Cancer 021001 nanoscience & nanotechnology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens nanomedicine 0104 chemical sciences anticancer agent Oncology Drug delivery Self-healing hydrogels Cancer research Nanomedicine cancer therapy 0210 nano-technology |
| Zdroj: | Cancers Cancers, Vol 12, Iss 940, p 940 (2020) |
| ISSN: | 2072-6694 |
| Popis: | Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several receptors that have a high binding affinity for HA, while these receptors are poorly expressed in normal body cells. HA-based drug delivery carriers can offer improved solubility and stability of anticancer drugs in biological environments and allow for the targeting of cancer treatments. Based on these benefits, HA has been widely investigated as a promising material for developing the advanced clinical cancer therapies in various formulations, including nanoparticles, micelles, liposomes, and hydrogels, combined with other materials. We describe various approaches and findings showing the feasibility of improvement in theragnosis probes through the application of HA. |
| Databáze: | OpenAIRE |
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