Morphologic characterization of preoperatively treated prostate cancer: toward a post-therapy histologic classification
| Autor: | Louis L. Pisters, Eleni Efstathiou, Kim Anh Do, Rita F. Tibbs, Neil A. Abrahams, Curtis A. Pettaway, Xuemei Wang, Christopher J. Logothetis, Paul F. Mathew, Patricia Troncoso |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Residual Tumors Urology medicine.medical_treatment Antineoplastic Agents urologic and male genital diseases Article Prostate cancer Prostate Medicine Cluster Analysis Humans skin and connective tissue diseases neoplasms Neoadjuvant therapy Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Prostatectomy business.industry Proportional hazards model Prostatic Neoplasms Retrospective cohort study Androgen Antagonists Middle Aged Prostate-Specific Antigen medicine.disease Prognosis Neoadjuvant Therapy Prostate-specific antigen medicine.anatomical_structure sense organs business |
| Zdroj: | European urology. 57(6) |
| ISSN: | 1873-7560 |
| Popis: | Preoperative treatment of prostate cancer (PCa) changes morphology of residual tumors so that the Gleason score is no longer valid.To codify morphologic features of preoperatively treated PCa and identify potential classifiers predictive of outcome.We performed a detailed morphologic evaluation of specimens obtained from 115 patients with high-risk PCa who had preoperative androgen ablation, alone or in combination with chemotherapy.Included hierarchical clustering analysis of morphologic characteristics, associations with other pathologic parameters, and univariate and multivariate analyses in search for associations with disease outcome.Based on hierarchical clustering analysis, we categorized pretreated prostate cancer in three morphologically distinct groups: group A, characterized by a predominance of cell clusters, cell cords, and isolated cells; group B tumors, by intact and fused small glands; and group C tumors by any degree of cribriform growth pattern or intraductal tumor spread. Univariate analysis identified associations between this grouping, pathologic tumor stage (p0.01) and residual tumor volume (p0.001). Presence of intraductal spread or cribriform pattern in biopsies was associated with group C tumors. The presence of cribriform or intraductal spread morphology and positive surgical margins were stronger predictors of biochemical relapse than pathologic stage on multivariate analysis. The number of specimens evaluated in this study was limited, and a prospective validation is warranted along with molecular studies to validate the proposed morphologic classifier.If validated, this classification will introduce uniformity in the selection of tissue samples for biomarker studies, facilitate the comparison of trials among different institutions, and may provide a new prognostic tool for preoperatively treated PCa. |
| Databáze: | OpenAIRE |
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