Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues
| Autor: | Margaret Warner, Jan-Åke Gustafsson, Andrea Morani |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Mammary gland Estrogen receptor Epithelium Autoimmune Diseases Prostate cancer Estrogen Receptor Modulators Internal medicine Internal Medicine medicine Estrogen Receptor beta Humans skin and connective tissue diseases Receptor Lung business.industry Uterus Estrogen Receptor alpha Estrogens medicine.disease body regions Endocrinology medicine.anatomical_structure Gene Expression Regulation Selective estrogen receptor modulator Estrogen Female business Extracellular matrix organization |
| Zdroj: | Journal of Internal Medicine. 264:128-142 |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | Morani A, Warner M, Gustafsson J-A ˚ (Karolinska Institutet, Novum, Huddinge, Sweden). Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues (Review). J Intern Med 2008; 264: 128-142. For the past 10 years it is known that oestrogen func- tions through the activation of two oestrogen recep- tors (ERa and ERb). To the great surprise of endocrinologists, ERb was found to be widely distrib- uted in tissues throughout the body including tissues previously considered as 'oestrogen insensitive'. The epithelium of the ventral prostate and lung as well as ovarian granulosa cells are ERa-negative but ERb- positive and in these tissues ERb seems to be involved in important physiological processes, like differentiation, extracellular matrix organization and stromal-epithelial communication. In tissues where both ERs are expressed, the two receptors seem to counteract each other. In the uterus, mammary gland and immune system, ERa promotes proliferation whereas ERb has pro-apoptotic and pro-differentiating functions. The challenge of the future will be to develop specific agonists, which can selectively acti- vate ⁄ inactivate either ERa or ERb. These pharmaceu- ticals are likely to be of clinical importance in the prevention or treatment of various diseases. |
| Databáze: | OpenAIRE |
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