Efficacy of a Single Dose of Basic Fibroblast Growth Factor: Clinical Observation for 1 Year

Autor: Kiyoshi Makiyama, Takeshi Oshima, Toru Furusaka, Ryoji Hirai, Hiroumi Matsuzaki, Hirotaka Suzuki
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Treatment response
Time Factors
Cord
Voice Quality
Basic fibroblast growth factor
Video Recording
GRBAS scale
Vocal Cords
Vibration
Injections
Laryngeal Diseases
Recombinant human basic fibroblast growth factor
030507 speech-language pathology & audiology
03 medical and health sciences
Speech and Hearing
chemistry.chemical_compound
0302 clinical medicine
Phonation
Speech Production Measurement
medicine
Humans
030223 otorhinolaryngology
Breathy voice
Aged
Aged
80 and over
Voice Disorders
Laryngoscopy
business.industry
Kymography
Maximum phonation time
Acoustics
Recovery of Function
Single injection
Middle Aged
LPN and LVN
Biomechanical Phenomena
Surgery
Treatment Outcome
Otorhinolaryngology
chemistry
Anesthesia
Female
Fibroblast Growth Factor 2
0305 other medical science
business
Zdroj: Journal of Voice. 30:761.e11-761.e17
ISSN: 0892-1997
DOI: 10.1016/j.jvoice.2015.09.018
Popis: Summary Objective Basic fibroblast growth factor promotes wound healing by accelerating healthy granulation and epithelialization. However, the duration of the effects of a single intracordal injection of basic fibroblast growth factor has not been established, and administration intervals and timing have yet to be standardized. Here, we administered a single injection to patients with insufficient glottic closure and conducted follow-up examinations with high-speed digital imaging to determine the duration of the treatment response. Study Design Case series. Methods For treatment, 20 µg/mL recombinant human basic fibroblast growth factor was injected into two vocal cords. The following examinations were performed before the procedure and at 3-month intervals for 12 months starting at 1 month postinjection: Grade, Roughness, Breathiness, Asthenia, and Strain (GRBAS) scale assessment, maximum phonation time, acoustic analysis, high-speed digital imaging, glottal wave analysis, and kymographic analysis. Results Postinjection, the GRBAS scale score decreased, and the maximum phonation time was prolonged. In addition, the mean minimum glottal area and mean minimum glottal distance decreased. These changes were significant at 12 months postinjection compared with preinjection. However, there were no significant changes in the vibrations of the vocal cord margins. Conclusions The intracordal injection of basic fibroblast growth factor improved insufficient glottic closure without reducing the vibrations of the vocal cord margins. This effect remained evident at 12 months postinjection. A single injection can be expected to yield a sufficient and persistent long-term effect.
Databáze: OpenAIRE
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