Epilepsy and autism: The authors’ study data
| Autor: | G S Golosnaya, T V Ananyeva, Petrukhin As, O A Pylayeva, A A Kholin, K. V. Voronkova |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test autism Electroencephalography medicine.disease epileptiform activity Psychiatry and Mental health Clinical Psychology Epilepsy Anesthesia Internal medicine medicine Autistic disorders epilepsy Autism antiepileptic therapy In patient Neurology. Diseases of the nervous system Neurology (clinical) Levetiracetam RC346-429 Psychology Sleep eeg medicine.drug |
| Zdroj: | Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 5, Iss 1S, Pp 19-23 (2013) |
| ISSN: | 2310-1342 2074-2711 |
| Popis: | A study was conducted to investigate electroclinical features in patients with epilepsy and autism and to determine the efficiency of antiepileptic therapy. A group of 113 patients aged 8 months to 10 years with autistic disorders was followed up. All the patients were divided into 6 groups, 3 of which consisted of those with the so-called epiautism. Epileptiform activity on awakening was found in 113 (63%) patients, of them 45% had benign epileptiform discharges of childhood (BEDCs) recorded as epileptiform activity also during sleep in all the patients with epiautism. The epiactivity index substantially increased in 94% of the patients during sleep as compared on awakening. Sleep EEG recording in a total of 113 patients revealed epileptiform activity in 71%, of them BEDCs were recorded in 73%, which was 26% greater than that on awakening. There was a rise in the presentation of multiregional activity during sleep. Epileptiform activity was more common in the central and temporal leads. Valproate used alone and in combination with other drugs was a major component of therapy in the children followed up. Levetiracetam, etosuximide, and other antiepileptic medications were also used. After therapy optimization, the majority of patients showed reduced activity on EEG; however, abnormalities remained in the higher psychic sphere. |
| Databáze: | OpenAIRE |
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