Elevation of Ouabainlike Compound Levels With Hypertonic Sodium Chloride Load in Rat Plasma and Tissues
| Autor: | Atsuo Goto, Hiroshi Nagoshi, Kaoru Yamada, Yoshitake Terano, Masao Omata |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Sodium Hypertonic Solutions Hypothalamus Radioimmunoassay chemistry.chemical_element Endogeny Sodium Chloride Ouabain Isomerism Internal medicine Adrenal Glands Blood plasma Internal Medicine medicine Animals Homeostasis Rats Wistar Analysis of Variance Hypernatremia business.industry medicine.disease Rats Endocrinology chemistry Pituitary Gland Potassium Tonicity Isotonic Solutions business Injections Intraperitoneal Software medicine.drug |
| Zdroj: | Hypertension. 30:94-98 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.30.1.94 |
| Popis: | Abstract A major biologically active endogenous digitalis-like factor in the mammalian body may be an isomer of ouabain (ouabainlike compound, OLC). However, the exact role of OLC in sodium homeostasis is still unclear, and acute isotonic volume expansion does not enhance the secretion of OLC. We tested the hypothesis that OLC may be more important in the response to acute hypertonic NaCl load rather than isotonic volume expansion. We injected intraperitoneally 2 mL of 20% NaCl solution into male Wistar rats (n=34) and measured OLC levels in plasma, hypothalamus, pituitary, and adrenal at baseline (n=10) and 1, 2, and 4 hours (n=8 for each). In response to hypertonic NaCl loading, plasma Na-K ratio was elevated at 2 and 4 hours ( P P P P P r =.51, P r =.48, P |
| Databáze: | OpenAIRE |
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