Vascular endothelial cadherin and vascular endothelial growth factor in periodontitis and smoking
| Autor: | Alpdogan Kantarci, Eser Sakallioglu, Müge Lütfioğlu, Ferda Pamuk, Umur Sakallıoğlu |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Periodontium Vascular Endothelial Growth Factor A medicine.medical_specialty Pathology Randomization VEGF receptors Gastroenterology smoking Vascular endothelial cadherin Crevicular fluid Random Allocation chemistry.chemical_compound VE-cadherin Periodontal disease Antigens CD Internal medicine medicine Humans Periodontitis periodontitis General Dentistry biology business.industry Smoking Gingival Crevicular Fluid Middle Aged Cadherins medicine.disease VEGF Vascular endothelial growth factor gingival crevicular fluid Otorhinolaryngology chemistry Case-Control Studies biology.protein business |
| Zdroj: | Oral Diseases. 21:263-269 |
| ISSN: | 1354-523X |
| Popis: | LUTFIOGLU, MUGE/0000-0003-1499-5902; Sakallioglu, Umur/0000-0002-8823-755X WOS: 000349986500017 PubMed: 24853861 OBJECTIVE: This study investigated the vascularization in periodontal disease process via revealing: (i) vascular endothelial cadherin (VE-cadherin) and vascular endothelial growth factor (VEGF) productions in periodontitis and (ii) the impact of smoking on this phenomenon. MATERIALS AND METHODS: Fifteen smokers and 15 non-smokers with/without periodontitis were allocated by split-mouth randomization regarding their smoking and periodontal statuses. The teeth with periodontitis in smokers (group 1), without periodontitis in smokers (group 2), with periodontitis in non-smokers (group 3), and without periodontitis in non-smokers (group 4) constituted the study groups. Gingival crevicular fluid (GCF) levels of VE-cadherin and VEGF were determined by ELISA to evaluate their profiles in the groups. RESULTS: There were increased VE-cadherin levels in groups 1 and 3 compared with groups 2 and 4 (P < 0.05). Group 2 demonstrated higher VE-cadherin level than group 4 (P < 0.05). Increased VEGF was noted in groups 1 and 3 compared with groups 2 and 4 (P < 0.05) with similar levels between groups 1 and 3 and groups 2 and 4 (P > 0.05). There were no correlations between the VE-cadherin and VEGF levels in all groups (P > 0.05). CONCLUSION: The results suggest that VE-cadherin and VEGF may increase in periodontitis, and smoking may uniquely cause VE-cadherin production in GCF. |
| Databáze: | OpenAIRE |
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