Diffusion tensor imaging in frontostriatal tracts is associated with executive functioning in very preterm children at 9 years of age
| Autor: | Hanna Kallankari, Virva Saunavaara, Riitta Parkkola, Leena Haataja, Tuula Kaukola, Mikko Hallman |
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| Přispěvatelé: | HUS Children and Adolescents, Children's Hospital, University of Helsinki, Helsinki University Hospital Area, Lastenneurologian yksikkö |
| Rok vydání: | 2020 |
| Předmět: |
INFANTS
Audiology ADULTS BORN Executive Function 0302 clinical medicine Pregnancy CONNECTIVITY 3123 Gynaecology and paediatrics Prospective Studies Neuropsychological assessment Child Children medicine.diagnostic_test WHITE-MATTER ALTERATIONS ABNORMALITIES White matter 05 social sciences Neuropsychology Brain BORN PRETERM Diffusion tensor imaging medicine.anatomical_structure Infant Extremely Premature Female Original Article Tractography Adult medicine.medical_specialty BIRTH 050105 experimental psychology 03 medical and health sciences Magnetic resonance imaging Fractional anisotropy medicine Humans Very Preterm Birth 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Premature birth business.industry Infant Newborn PATHWAYS Diffusion Magnetic Resonance Imaging Pediatrics Perinatology and Child Health Anisotropy Frontostriatal tracts MICROSTRUCTURE FETAL-GROWTH RESTRICTION business Neurocognitive 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Pediatric Radiology |
| ISSN: | 1432-1998 0301-0449 |
| DOI: | 10.1007/s00247-020-04802-1 |
| Popis: | Background Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later. Objective The aim of the study was to evaluate the impact of prematurity on microstructure of frontostriatal tracts in children with no severe neurologic impairment, and to study whether the diffusion tensor imaging metrics of frontostriatal tracts correlate to executive functioning. Materials and methods The prospective cohort study comprised 54 very preterm children (mean gestational age 28.8 weeks) and 20 age- and gender-matched term children. None of the children had severe neurologic impairment. The children underwent diffusion tensor imaging and neuropsychological assessments at a mean age of 9 years. We measured quantitative diffusion tensor imaging metrics of frontostriatal tracts using probabilistic tractography. We also administered five subtests from the Developmental Neuropsychological Assessment, Second Edition, to evaluate executive functioning. Results Very preterm children had significantly higher fractional anisotropy and axial diffusivity values (P<0.05, corrected for multiple comparison) in dorsolateral prefrontal caudate and ventrolateral prefrontal caudate tracts as compared to term-born children. We found negative correlations between the diffusion tensor imaging metrics of frontostriatal tracts and inhibition functions (P<0.05, corrected for multiple comparison) in very preterm children. Conclusion Prematurity has a long-term effect on frontostriatal white matter microstructure that might contribute to difficulties in executive functioning. |
| Databáze: | OpenAIRE |
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