Cerebellar function and ischemic brain lesions in migraine patients from the general population
| Autor: | Albertine Ellen Smit, Mark C. Kruit, Michel D. Ferrari, Corinne G.C. Horlings, Bastiaan J Koutstaal, Inge H. Palm-Meinders, Mark A. van Buchem, Gisela M. Terwindt, Hille Koppen, Lenore J. Launer, Chris I. De Zeeuw, Jos N. van der Geest, Bas K Koekkoek, Henk-Jan Boele, Bas R. Bloem |
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| Přispěvatelé: | Neurosciences, Netherlands Institute for Neuroscience (NIN) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Cerebellum medicine.medical_specialty cerebellum Aura Migraine Disorders Population infarcts Article Brain Ischemia Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans magnetic resonance imaging Longitudinal Studies education Familial hemiplegic migraine Migraine Aged education.field_of_study medicine.diagnostic_test hemiplegic migraine business.industry Magnetic resonance imaging General Medicine Middle Aged Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] medicine.disease Migraine with aura 030104 developmental biology medicine.anatomical_structure Population Surveillance Cerebellar cortex Cardiology Physical therapy Female Neurology (clinical) medicine.symptom business Photic Stimulation Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Cephalalgia, 37, 2, pp. 177-190 Cephalalgia, 37(2), 177-190. SAGE Publications Ltd Cephalalgia, 37(2), 177-190 Cephalalgia, 37(2), 177-190. SAGE Publications Cephalalgia Cephalalgia, 37, 177-190 |
| ISSN: | 0333-1024 |
| Popis: | ObjectiveThe objective of this article is to obtain detailed quantitative assessment of cerebellar function and structure in unselected migraine patients and controls from the general population.MethodsA total of 282 clinically well-defined participants (migraine with aura n = 111; migraine without aura n = 89; non-migraine controls n = 82; age range 43–72; 72% female) from a population-based study were subjected to a range of sensitive and validated cerebellar tests that cover functions of all main parts of the cerebellar cortex, including cerebrocerebellum, spinocerebellum, and vestibulocerebellum. In addition, all participants underwent magnetic resonance imaging (MRI) of the brain to screen for cerebellar lesions. As a positive control, the same cerebellar tests were conducted in 13 patients with familial hemiplegic migraine type 1 (FHM1; age range 19–64; 69% female) all carrying a CACNA1A mutation known to affect cerebellar function.ResultsMRI revealed cerebellar ischemic lesions in 17/196 (8.5%) migraine patients and 3/79 (4%) controls, which were always located in the posterior lobe except for one control. With regard to the cerebellar tests, there were no differences between migraine patients with aura, migraine patients without aura, and controls for the: (i) Purdue-pegboard test for fine motor skills (assembly scores p = 0.1); (ii) block-design test for visuospatial ability (mean scaled scores p = 0.2); (iii) prism-adaptation task for limb learning (shift scores p = 0.8); (iv) eyeblink-conditioning task for learning-dependent timing (peak-time p = 0.1); and (v) body-sway test for balance capabilities (pitch velocity score under two-legs stance condition p = 0.5). Among migraine patients, those with cerebellar ischaemic lesions performed worse than those without lesions on the assembly scores of the pegboard task ( p ConclusionsUnselected migraine patients from the general population show normal cerebellar functions despite having increased prevalence of ischaemic lesions in the cerebellar posterior lobe. Except for an impaired pegboard test revealing deficits in fine motor skills, these lesions appear to have little functional impact. In contrast, all cerebellar functions were significantly impaired in participants with FHM1. |
| Databáze: | OpenAIRE |
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