Safety and tolerability of ultrasound-guided synovial needle biopsy in Japanese arthritis patients
| Autor: | Tsutomu Takeuchi, Chihiro Takahashi, Katsuya Suzuki, Y. Inoue, Yuko Kaneko, Yasushi Kondo, K. Sakata |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Image-Guided Biopsy medicine.medical_specialty Arthritis 03 medical and health sciences 0302 clinical medicine Rheumatology Japan Biopsy medicine Humans 030212 general & internal medicine Ultrasonography Interventional 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Ultrasound Biopsy Needle medicine.disease Ultrasound guided Ultrasound guidance Tolerability Needle biopsy Radiology business |
| Zdroj: | Modern rheumatology. 31(5) |
| ISSN: | 1439-7609 |
| Popis: | We sought to clarify the safety and tolerability of ultrasound (US)-guided synovial needle biopsy in hand and knee joints in Japanese arthritis patients.A total of nine consecutive arthritis patients were recruited and scheduled for US-guided synovial needle biopsies. Patients completed a safety questionnaire and patient-reported outcomes (PRO) data of joint pain, stiffness, and swelling pre- and postbiopsy. We also recorded patients' characteristics and willingness to undergo a second biopsy by the same technique. All synovial needle biopsy samples were assessed with pathological and microbial examination to verify whether clinical evaluation was possible.Five and 4 patients underwent US-guided biopsy from hand and knee joints, respectively. PRO data showed no significant differences in pain, swelling, or stiffness levels before and after biopsy, with a mean 11.8 samples collected per procedure. No significant complications, including joint infection, bleeding, or vasovagal signs, were reported. Histologically adequate synovial tissue was identified in 83 (78%) samples. We were able to submit the biopsy samples to pathological and bacterial analysis to exclude septic arthritis.We demonstrated that a minimally invasive US-guided needle biopsy is a safe and well-tolerated procedure and the synovial tissue collected was of adequate quality for pathological analysis. |
| Databáze: | OpenAIRE |
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