Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases
| Autor: | Céline Van Themsche, Julie Couillard, Yves St-Pierre |
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| Rok vydání: | 2004 |
| Předmět: |
Cell type
Transgene Clinical Biochemistry Anti-Inflammatory Agents Antineoplastic Agents Matrix Metalloproteinase Inhibitors Matrix metalloproteinase Biology Bioinformatics Models Biological Dinoprostone Gene Expression Regulation Enzymologic Epigenesis Genetic Proinflammatory cytokine Neoplasms Consensus Sequence Drug Discovery Gene expression medicine Humans Enzyme Inhibitors Promoter Regions Genetic Protein Kinase C Epigenesis Inflammation Pharmacology Regulation of gene expression Binding Sites Genes Transgenic Suicide NF-kappa B Cancer Genetic Therapy Oligonucleotides Antisense medicine.disease Isoenzymes Matrix Metalloproteinase 9 Drug Design Enzyme Induction Molecular Medicine Mitogen-Activated Protein Kinases Phytotherapy Signal Transduction Transcription Factors |
| Zdroj: | Expert Opinion on Therapeutic Targets. 8:473-489 |
| ISSN: | 1744-7631 1472-8222 |
| DOI: | 10.1517/14728222.8.5.473 |
| Popis: | The need to pharmacologically control the proteolytic activity of matrix metalloproteinases (MMPs) has been commonly acknowledged, despite its limited efficacy in clinical trials. Among the reasons that explain this failure is our limited understanding of the signals that control the expression of MMPs in different cell types during different pathological conditions. Thus, future therapies must rely on more selective approaches. With the continually increasing body of proof implicating MMPs in a large number of diseases, it has become a priority to establish the pertinence of molecules involved in the signalling pathways leading to the expression of these enzymes. MMP-9 is a case in point: its dramatic overexpression in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention. In this article, recent progress in the signalling pathways that regulate MMP-9 expression is reviewed, and the latest strategies to be considered in the search for a specific inhibitor of its expression are presented. |
| Databáze: | OpenAIRE |
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