Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds

Autor: Roy J. Heyne, Minhui Ouyang, Tina Jeon, Qinmu Peng, Hao Huang, Lina F. Chalak
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Brain development
Support Vector Machine
QH301-705.5
Science
Early detection
brain development
Neuroimaging
Biology
General Biochemistry
Genetics and Molecular Biology
diffusion MRI
03 medical and health sciences
0302 clinical medicine
Dendritic Arborization
Child Development
Image Interpretation
Computer-Assisted
Humans
Biology (General)
cortical microstructure
030304 developmental biology
Cerebral Cortex
0303 health sciences
General Immunology and Microbiology
behavior
infants
General Neuroscience
Cortical architecture
Infant
Newborn
Cognition
General Medicine
prediction
Tailored Intervention
030104 developmental biology
Diffusion Magnetic Resonance Imaging
Neurodevelopmental Disorders
Child
Preschool
Biomarker (medicine)
Medicine
Female
Neuroscience
030217 neurology & neurosurgery
Diffusion MRI
Research Article
Human
Zdroj: eLife
eLife, Vol 9 (2020)
ISSN: 2050-084X
Popis: Brain cerebral cortical architecture encoding regionally differential dendritic arborization and synaptic formation at birth underlies human behavior emergence at 2 years of age. Brain changes in 0-2 years are most dynamic across lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development, and identify biomarkers for early detection and tailored intervention in atypical development. Here, we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders.
Databáze: OpenAIRE
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