Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds
Autor: | Roy J. Heyne, Minhui Ouyang, Tina Jeon, Qinmu Peng, Hao Huang, Lina F. Chalak |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Brain development Support Vector Machine QH301-705.5 Science Early detection brain development Neuroimaging Biology General Biochemistry Genetics and Molecular Biology diffusion MRI 03 medical and health sciences 0302 clinical medicine Dendritic Arborization Child Development Image Interpretation Computer-Assisted Humans Biology (General) cortical microstructure 030304 developmental biology Cerebral Cortex 0303 health sciences General Immunology and Microbiology behavior infants General Neuroscience Cortical architecture Infant Newborn Cognition General Medicine prediction Tailored Intervention 030104 developmental biology Diffusion Magnetic Resonance Imaging Neurodevelopmental Disorders Child Preschool Biomarker (medicine) Medicine Female Neuroscience 030217 neurology & neurosurgery Diffusion MRI Research Article Human |
Zdroj: | eLife eLife, Vol 9 (2020) |
ISSN: | 2050-084X |
Popis: | Brain cerebral cortical architecture encoding regionally differential dendritic arborization and synaptic formation at birth underlies human behavior emergence at 2 years of age. Brain changes in 0-2 years are most dynamic across lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development, and identify biomarkers for early detection and tailored intervention in atypical development. Here, we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders. |
Databáze: | OpenAIRE |
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