Pioglitazone decreases postprandial accumulation of remnant lipoproteins in insulin-resistant smokers
| Autor: | Gerald M. Reaven, C. Lamendola, Fahim Abbasi, Elizabeth Leary |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Blood sugar Blood lipids chemistry.chemical_compound Endocrinology Insulin resistance Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Triglycerides Hypertriglyceridemia Pioglitazone Triglyceride business.industry Insulin Smoking Fasting Middle Aged Postprandial Period medicine.disease Cholesterol Postprandial chemistry Cardiovascular Diseases Female Thiazolidinediones Insulin Resistance business medicine.drug |
| Zdroj: | Diabetes, Obesity and Metabolism. 11:779-785 |
| ISSN: | 1463-1326 1462-8902 |
| DOI: | 10.1111/j.1463-1326.2009.01041.x |
| Popis: | BACKGROUND Fasting hypertriglyceridaemia has been reported to occur commonly in cigarette smokers and is thought to increase cardiovascular disease (CVD) risk in these individuals. More recently, it has been suggested that an increase in non-fasting triglycerides, rather than fasting hypertriglyceridaemia, is an independent CVD risk factor. METHODS In this study, we divided 24 smokers into insulin-resistant (IR) and insulin-sensitive (IS) groups by determining their steady-state plasma glucose concentrations during the insulin suppression test and compared fasting and daylong postprandial accumulation of total triglycerides and remnant lipoprotein (RLP) concentrations, before and after 3 months of pioglitazone (PIO) administration. RESULTS The two groups were similar in age, body mass index, race and gender distribution, but differed dramatically in insulin sensitivity. Baseline fasting and postprandial triglyceride, RLP cholesterol and RLP triglyceride concentrations were significantly higher in the IR smokers (p=0.01 to |
| Databáze: | OpenAIRE |
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