Resting state functional connectivity correlates of rumination and worry in internalizing psychopathologies

Autor:	Jagan Jimmy, Fini Chang, Olusola Ajilore, K. Luan Phan, Heide Klumpp, Cope Feurer, Scott A. Langenecker
Rok vydání:	2021
Předmět:	Rest media_common.quotation_subject Precuneus Inferior frontal gyrus Anxiety Article 03 medical and health sciences 0302 clinical medicine medicine Humans Middle frontal gyrus Default mode network media_common Resting state fMRI Brain Anxiety Disorders Magnetic Resonance Imaging 030227 psychiatry Pessimism Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Rumination medicine.symptom Worry Psychology 030217 neurology & neurosurgery Clinical psychology
Zdroj:	Depress Anxiety
ISSN:	1520-6394 1091-4269
DOI:	10.1002/da.23142
Popis:	Background Rumination and worry are repetitive negative thinking (RNT) tendencies that contribute to the development and maintenance of internalizing psychopathologies. Accruing data suggest rumination and worry represent overlapping and unique transdiagnostic cognitive processes. Yet, prior neuroimaging research has mostly focused on rumination in depression, which points to involvement of resting-state brain activity in default mode, executive, salience, and/or affective networks. Methods The current study examined relations between brain activity during rest and RNT in a transdiagnostic sample. Resting-state fMRI data was analyzed in 80 unmedicated patients with internalizing conditions. Regression analysis, controlling for anxiety and depression symptoms, was performed with seed regions implicated in default mode, executive, salience, and affective networks. Rumination and worry were assessed with standard self-report measures. Results Whole-brain regression results showed more rumination and worry jointly corresponded with greater positive resting-state functional connectivity (rsFC) between the amygdala and prefrontal regions (i.e., middle frontal gyrus, inferior frontal gyrus). Conversely, more worry (controlling for rumination) corresponded with greater negative rsFC between amygdala and precuneus. No significant results were observed for rumination alone (controlling for worry). Conclusions Findings indicate the affective network plays a role in RNT, and distinct patterns of connectivity between amygdala and regions implicated in the executive and default mode networks were observed across patients with internalizing conditions. Results suggest different mechanisms contribute to RNT as a unitary construct and worry as a unique construct.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb9627e388b30cd4a2127d171604f35 https://doi.org/10.1002/da.23142 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.