Hair cortisol and the relationship with chronic pain and quality of life in endometriosis patients

Autor: Didi D.M. Braat, Annemiek W. Nap, Tamas Kozicz, Tineke van Rijn, Gé S.F. Ruigt, Joukje M. Oosterman, Magdalena A. Ferdek, Mieke van Aken, Ard Peeters
Rok vydání: 2018
Předmět:
Adult
Hypothalamo-Hypophyseal System
Hydrocortisone
Endocrinology
Diabetes and Metabolism
Endometriosis
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
Pituitary-Adrenal System
Physiology
Disease
Biologische psychologie
03 medical and health sciences
0302 clinical medicine
Endocrinology
Quality of life
Stress
Physiological
medicine
Humans
Chronic stress
In patient
Biological Psychiatry
Health related quality of life
030219 obstetrics & reproductive medicine
Neuro- en revalidatiepsychologie
Endocrine and Autonomic Systems
business.industry
Action
intention
and motor control
Pelvic pain
Neuropsychology and rehabilitation psychology
Chronic pain
Perception
Action and Control [DI-BCB_DCC_Theme 2]
Plasticity and Memory [DI-BCB_DCC_Theme 3]
Middle Aged
medicine.disease
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
Psychiatry and Mental health
Quality of Life
Biological psychology
Female
Chronic Pain
medicine.symptom
business
Stress
Psychological
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Hair
Zdroj: Psychoneuroendocrinology, 89, pp. 216-222
Psychoneuroendocrinology, 89, 216-222
ISSN: 0306-4530
Popis: Contains fulltext : 183001.pdf (Publisher’s version ) (Closed access) Endometriosis is a chronic estrogen-dependent disease in which pelvic pain is the dominant symptom. The negative effects of endometriosis on the life of women with this disease can be a cause of stress. Stress levels can be measured in different ways, mostly reflecting acute stress responses. Hair cortisol measurements are a reflection of long-term systematic cortisol levels. In this study a first attempt is made to measure cortisol levels in hair of endometriosis patients in comparison with healthy controls. Moreover, it is explored whether chronic pain symptoms as well as different aspects of Health Related Quality of Life (HRQoL) are associated with hair cortisol levels in women with endometriosis. Results show that the mean hair cortisol level is significantly higher in women with endometriosis compared to healthy controls (p = 0.018). There is a positive correlation between hair cortisol level and HRQoL in patients but not in controls (Rho 0.426). The level of hair cortisol does not correlate with the reported pain intensity in patients (Rho -0.082). These results are indicative of an altered HPA-axis function in endometriosis patients, possibly caused by higher chronic stress level in these patients. Moreover, a potential explanation for the positive correlation of cortisol with the HRQoL in these patients is that patients with a high HRQoL have an adequate stress response by increasing their cortisol levels as a response to physical and emotional stress induced by the endometriosis. 7 p.
Databáze: OpenAIRE
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