The effect of apolipoprotein A-I and perfluorocarbon emulsion on the production of specific antibodies in mice
| Autor: | Yuliya Gritsyna, V. K. Zhalimov, Oleg S. Morenkov |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Apolipoprotein A-I Apolipoprotein B biology Chemistry medicine.medical_treatment Immunogenicity Public Health Environmental and Occupational Health Brief Communication Specific antibody Titer Infectious Diseases Immunization Antigen Perfluorocarbons Emulsion medicine biology.protein Immunology and Allergy Adjuvants Adsorption Adjuvant Synthetic biology |
| Zdroj: | Clinical and Experimental Vaccine Research |
| ISSN: | 2287-366X 2287-3651 |
| Popis: | Adjuvants are often required to improve the potentially low immunogenicity of vaccines. In this study, it is proposed to use an emulsion based on fluorocarbons as an adjuvant. Since this emulsion adsorbs only a small range of proteins, apolipoprotein A-I (ApoAI) was used as an anchor. Antigen and ApoAI were combined by creating a fusion construct. Results showed that the combined use of a perfluorocarbon emulsion and ApoAI during immunization significantly increases the specific antibody titer in mice and in its effectiveness this system is close to the incomplete Freund's adjuvant. |
| Databáze: | OpenAIRE |
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