Acquisition of an appetitive behavior reverses the effects of long-term treatment with lithium in rats
| Autor: | Simona Mangiavacchi, Simona Scheggi, Flavio Masi, Carla Gambarana, M.G. De Montis, A Romeo, Alessandro Tagliamonte |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Time Factors microdialysis media_common.quotation_subject Carbohydrates Appetite Appetite Stimulants Nucleus accumbens Nucleus Accumbens Rats Sprague-Dawley chemistry.chemical_compound Neurochemical escape deficit Antimanic Agents Stress Physiological Dopamine Internal medicine Avoidance Learning medicine Noxious stimulus Animals Chronic stress motivated behavior dopamine nucleus accumbens shell Maze Learning media_common General Neuroscience Dopaminergic Feeding Behavior Antidepressive Agents Rats Endocrinology chemistry Chronic Disease Lithium chloride Lithium Chloride Psychology Reinforcement Psychology medicine.drug |
| Popis: | Rats exposed to a long-term treatment with lithium chloride develop a deficit of avoidance accompanied by a reduction in the basal levels of extraneuronal dopamine and in dopamine accumulation in the nucleus accumbens shell after acute uptake inhibition. Such a condition is similar to that of an experimental model of depression induced by exposing rats to a chronic stress procedure. Rats exposed to chronic stress are also unable to acquire an appetitive behavior sustained by a highly palatable food. Thus, it was studied whether rats fed a diet containing lithium would develop an appetitive behavior induced by a pure hedonic stimulus. Rats on the lithium diet developed a clear-cut escape deficit condition accompanied by a decreased dopamine output in the nucleus accumbens shell; nevertheless, they learned the appetitive behavior within a similar period to controls. The development of the appetitive behavior coincided with the recovery of the capacity to avoid a noxious stimulus and with the return of the dopaminergic transmission in the nucleus accumbens shell to values similar to those of control rats. It may be concluded that the mechanism of action underlying the behavioral and neurochemical sequelae of a chronic stress is distinct from that of the analogous effects produced by lithium. |
| Databáze: | OpenAIRE |
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