Influence of estrogen-progestin replacement therapy and exercise on lumbar spine mobility and low back symptoms in a healthy early postmenopausal female population: a 2-year randomized controlled trial
| Autor: | J. E. Heikkinen, H. K. Väänänen, G. Wilen-Rosenqvist, J. H. V. Vanharanta, E. Kurttila-Matero, Kari S. Lankinen, Eero Kyllönen |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Hormone Replacement Therapy Placebo law.invention Disability Evaluation Randomized controlled trial law Internal medicine Medicine Medroxyprogesterone acetate Humans Orthopedics and Sports Medicine Pain Measurement business.industry Estradiol valerate Lumbosacral Region Reproducibility of Results Estrogens Middle Aged medicine.disease Low back pain Spine Exercise Therapy Menopause Clinical trial Postmenopause Transgender hormone therapy Physical therapy Surgery Female Original Article medicine.symptom Progestins business Low Back Pain medicine.drug |
| Zdroj: | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 7(5) |
| ISSN: | 0940-6719 |
| Popis: | The purpose of this study was to examine the influence of estrogen-progestin replacement therapy and exercise on the lumbar spine mobility and back symptoms of early postmenopausal women. The population sample consisted of 78 healthy, 49- to 55-year-old women, 0.5–5 years after menopause, who were randomized into three groups, two receiving different protocols of estradiol valerate combined with medroxyprogesterone acetate replacement therapy, and the third group a placebo. These groups were then randomized into exercise and control cases and monitored for 2 years. The mobility of the lumbar spine was measured and symptoms investigated using the Million and Oswestry pain and disability questionnaires and pain drawings at the baseline and after 1 and 2 years. During the follow-up, the mobility of the lumbar spine decreased in all six groups. The decrease was most evident in those who had been the most flexible at baseline (P < 0.0001). The decrease was less notable in the hormone replacement therapy groups than in the control group. When the replacement therapy groups were pooled together, the difference was significant at a P < 0.05 level. No difference was seen between the hormone combinations. The exercise intervention was insufficient to influence lumbar spine mobility. Only sporadic cases of back symptoms appeared and disappeared among the subjects during the follow-up, and no preventive or aggravating effects of hormone replacement therapy or the exercise program on symptoms were detected. |
| Databáze: | OpenAIRE |
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