A comparison between gastrointestinal blood loss caused by tilcotil (Ro 12-0068) and aspirin in normal volunteers
| Autor: | Howard A. Bird, F. S. Jeunet, D. B. Galloway, V. Wright, M. E. Pickup, L. Bamford, M. McEvoy, E. W. Gasgoine |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system Anti-Inflammatory Agents Thiazines Kidney Gastroenterology Piroxicam Pharmacotherapy Blood loss Internal medicine Acetylglucosaminidase medicine Humans Aspirin business.industry General Medicine Middle Aged Crossover study Treatment period Surgery Normal volunteers Aspirin therapy Female Gastrointestinal Hemorrhage business medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 8:9-13 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007998209109750 |
| Popis: | An open crossover study was carried out in 6 normal volunteers to measure faecal blood loss caused by tilcotil (Ro 12-0068), a new anti-inflammatory drug, compared with that caused by enteric-coated aspirin. Subjects were allocated at random to receive either single doses of 20 mg tilcotil daily or 900 mg aspirin 4-times daily, reducing to a maximum tolerated dose, over a period of 2 weeks before being crossed over to the alternative medication for a further 2 weeks. Faecal specimens passed during 4 consecutive days in a run-in-period of 1 week, in each treatment period, and in the 2 weeks after the finish of drug therapy were analyzed for blood using a radioactive labelling method. The results showed that faecal blood loss was lower and it did not produce any haematological or biochemical abnormalities or any increase in urinary N-acetyl-beta-glucosaminidase activity indicative of renal damage. It is suggested that the method described provides a simple and reliable means of comparing faecal blood loss with different anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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