Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease
| Autor: | Suzana Erico Tanni, Camila Renata Corrêa, Renata Antonialli F. do Amaral, Irma Godoy, Nilva Regina Gelamo Pelegrino, Aparecida Y.O. Angeleli |
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| Rok vydání: | 2012 |
| Předmět: |
Spirometry
Adult Male medicine.medical_specialty Respiratory System Inflammation Systemic inflammation Gastroenterology Pulmonary Disease Chronic Obstructive Internal medicine medicine Humans Interleukin 6 Aged COPD biology medicine.diagnostic_test business.industry C-reactive protein Smoking Sputum General Medicine Pneumonia Middle Aged medicine.disease respiratory tract diseases Respiratory Function Tests C-Reactive Protein Immunology biology.protein Cytokines Regression Analysis Female medicine.symptom business Biomarkers |
| Zdroj: | The American journal of the medical sciences. 345(6) |
| ISSN: | 1538-2990 |
| Popis: | Background The markers that characterize local and systemic inflammation in chronic obstructive pulmonary disease (COPD) remain unclear, as do their correlations with smoking status and presence of disease. The aim of this study was to assess markers of inflammation in the peripheral blood and airways of current smokers without COPD, of current smokers with COPD and of ex-smokers with COPD. Methods In this study, 17 current smokers with COPD (mean age: 58.2 ± 9.6 years; mean forced expiratory volume in 1 second [FEV 1 ]: 56.1 ± 15.9%), 35 ex-smokers with COPD (mean age: 66.3 ± 7.3 years; mean FEV 1 : 47.9 ± 17.2%) and 20 current smokers without COPD (mean age: 49.1 ± 6.2 years; mean FEV 1 : 106.5 ± 15.8%) were evaluated. Spirometry findings, body composition and serum/induced sputum concentrations of tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8 and IL-10, together with serum C-reactive protein (CRP) levels, were assessed. Results Serum TNF-α concentration was higher in all current smokers than in ex-smokers with COPD. In current smokers without COPD, serum CRP level was lower than in ex-smokers with COPD and significantly lower than in current smokers with COPD. Sputum TNF-α concentration was higher in current and ex-smokers with COPD than in current smokers without COPD. Multiple regression analyses showed that serum TNF-α was associated with active smoking, and serum CRP and sputum TNF-α were associated with COPD diagnosis. Conclusions Smoking is associated with higher systemic inflammation in patients with COPD. Current findings also support the hypothesis that smoking and COPD have different effects on the regulation of airway and systemic inflammatory processes. |
| Databáze: | OpenAIRE |
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