Activity of buforin II alone and in combination with azithromycin and minocycline against Cryptosporidium parvum in cell culture
| Autor: | Anna Fineo, Andrea Giacometti, Maria Simona Del Prete, Giorgio Scalise, Oscar Cirioni, Francesco Barchiesi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Microbiology (medical)
Drug Evaluation Preclinical Peptide Minocycline Biology Azithromycin Buforin II Microbiology Anti-Infective Agents medicine Tumor Cells Cultured Animals Humans Pharmacology (medical) Drug Interactions Pharmacology chemistry.chemical_classification Cryptosporidium parvum Proteins Biological activity Drug interaction biology.organism_classification In vitro Infectious Diseases chemistry medicine.drug |
| Zdroj: | The Journal of antimicrobial chemotherapy. 47(1) |
| ISSN: | 0305-7453 |
| Popis: | The in vitro anti-cryptosporidial activity of buforin II alone and in combination with azithromycin and minocycline was investigated. Buforin II showed moderate activity, which increased with increasing concentration to 55.7% suppression of growth at 20 microM. Moreover, its activity was enhanced when it was combined with either azithromycin or minocycline with >90% parasite reduction at the highest concentration tested. Buforin II may be active in inhibiting Cryptosporidium parvum growth in vitro upon combination with either azithromycin or minocycline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|