Cytokine receptor expression in leukaemic cells
| Autor: | Heddy Zola, Ram Seshadri, Ian Beckman, L. Flego, Naomi Siderius |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
Receptor expression medicine.medical_treatment Biology Antigens CD Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Receptors Cytokine Receptor Common gamma chain Leukemia Hairy Cell Leukemia Janus kinase 1 Suppressor of cytokine signaling 1 Receptors Interleukin-2 Receptors Interleukin Hematology Leukemia Lymphocytic Chronic B-Cell Receptors Interleukin-6 Cytokine Oncology Leukemia Myeloid Interleukin-21 receptor Acute Disease Immunology Cytokine receptor Cell Division |
| Zdroj: | Leukemia Research. 18:347-355 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/0145-2126(94)90018-3 |
| Popis: | Cytokines have been postulated to play important roles in tumour biology and in the host response to tumours, and a number of therapeutic modalities involving cytokines have been proposed. If patients are to be treated with cytokines, or cytokine inhibitors, it will be important to determine the potential for direct action of the cytokine on the tumour cells. In this study, a high-sensitivity immunofluorescence technique is used to determine the expression of a number of cytokine receptors on a total of 115 leukaemic samples. The results show that many leukaemic samples express low levels of cytokine receptors, and that malignancies of a particular type are heterogeneous with respect to receptor expression. In vitro culture experiments show, as expected, that receptor expression is a necessary but not sufficient requirement for responsiveness to cytokines. The cytokine receptor phenotype may provide useful additional clinical and prognostic information, and should be determined particularly for patients undergoing treatment with cytokines or cytokine inhibitors. |
| Databáze: | OpenAIRE |
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