Soluble transferrin receptor as an indicator of iron deficiency in HIV-infected infants
| Autor: | Amanda L. Ray, Francis Mmiro, Michelle O. Ricks, Christopher M. Ndugwa, Richard D. Semba |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Anemia Population HIV Infections Transferrin receptor Internal medicine Receptors Transferrin Humans Medicine education Soluble transferrin receptor education.field_of_study Anemia Iron-Deficiency Anthropometry biology business.industry Body Weight Area under the curve Infant Orosomucoid Iron deficiency medicine.disease Body Height Ferritin C-Reactive Protein Cross-Sectional Studies Endocrinology ROC Curve Iron-deficiency anemia Ferritins Pediatrics Perinatology and Child Health Immunology biology.protein business Biomarkers |
| Zdroj: | Annals of Tropical Paediatrics. 27:11-16 |
| ISSN: | 1465-3281 0272-4936 |
| Popis: | Iron deficiency is common in human immunodeficiency virus (HIV)-infected infants in sub-Saharan Africa. It is not known whether soluble transferrin receptor (sTfR) is a good indicator of iron deficiency in infants with HIV.We evaluated sTfR as an indicator of iron deficiency in 134 HIV-infected 9-month-old infants in Kampala, Uganda. Ferritin12 microg/L and microcytic, hypochromic anaemia were used as indicators of iron deficiency, respectively. The presence of inflammation was indicated by C-reactive protein5 mg/L or alpha1-acid glycoprotein1 g/L.Receiver operator characteristic curves showed that the area under the curve was 0.67 when sTfR receptor was compared with low ferritin and 0.71 when sTfR was compared with microcytic, hypochromic anaemia. The appropriate calculated cut-offs of sTfR3.74 microg/mL (43.98 nmol/L) and3.53 microg/mL (41.55 nmol/L) show adequate specificities of 60% and sensitivities of 63% and 69% for low ferritin and microcytic, hypochromic anaemia, respectively. C-reactive protein and alpha 1-acid glycoprotein were strongly correlated with serum ferritin (r=0.371 and r=0.458, respectively, both p0.0001) but were not correlated with sTfR (r=0.009 and r= -0.003, respectively, both p=0.9). In all, 78.6% of infants had alpha l-acid glycoprotein1 g/L and 54.7% had C-reactive protein5 g/L.Soluble TfR appears to be an adequate indicator of iron deficiency in HIV-infected infants. |
| Databáze: | OpenAIRE |
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