CDK4 overexpression is a predictive biomarker for resistance to conventional chemotherapy in patients with osteosarcoma
| Autor: | Tsukasa Yonemoto, Akinobu Araki, Hiroki Nagase, Shintaro Iwata, Hiroto Kamoda, Yasutoshi Tatsumi, Miki Ohira, Makiko Itami, Hideyuki Kinoshita, Takeshi Ishii, Toshinori Tsukanishi, Yoko Hagiwara |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Adolescent Cell Survival Pyridines medicine.medical_treatment Gene Dosage Copy number analysis Bone Neoplasms Palbociclib Gene mutation Piperazines Cell Line Tumor Internal medicine Exome Sequencing Biomarkers Tumor medicine Humans Child Cell Proliferation Cisplatin Comparative Genomic Hybridization Osteosarcoma Chemotherapy business.industry Gene Expression Profiling Cyclin-Dependent Kinase 4 Cancer General Medicine medicine.disease Up-Regulation Drug Resistance Neoplasm Child Preschool business Comparative genomic hybridization medicine.drug |
| Zdroj: | Oncology Reports. 46 |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2021.8086 |
| Popis: | Osteosarcoma (OS) is the most common malignant bone tumor, and its sensitivity to preoperative chemotherapy is a significant prognostic factor. The present study aimed to identify potential genomic markers for the prediction of chemosensitivity in patients with OS using a genomic approach. A total of 50 pediatric and adolescent patients diagnosed with high‑grade OS were selected. Each pre‑therapeutic biopsy sample was subjected to comparative genomic hybridization array analysis and targeted exome sequencing. Although no recurrent gene mutation was observed in chemoresistant tumors, copy number analysis detected recurrent gain of chromosome 12q14.1, which was significantly more frequent (5/21; 24%) in the poor responder cohort than in the good responder cohort (0/29; 0%; P |
| Databáze: | OpenAIRE |
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