A study on lung toxicity of respirable hard metal dusts in rats
| Autor: | Z. Adamis, E. Tátrai, J. Kárpáti, G. Ungváry, Koichi Honma |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pulmonary toxicity Rats Sprague-Dawley chemistry.chemical_compound Occupational Exposure Lactate dehydrogenase medicine Animals Lung Hungary Hard metal medicine.diagnostic_test biology Chemistry Public Health Environmental and Occupational Health Acid phosphatase Dust General Medicine Rats respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure Metals Metallurgy Toxicity biology.protein Lymph Bronchoalveolar Lavage Fluid |
| Zdroj: | The Annals of Occupational Hygiene. 41:515-526 |
| ISSN: | 0003-4878 |
| DOI: | 10.1016/s0003-4878(97)00014-8 |
| Popis: | The aetiology of hard metal lung disease has not been clarified so far. The pulmonary toxicity of respirable dusts collected in a hard metal factory was studied in vivo in rats. The effect of the samples was examined 1, 4, 7 and 30 days after single intratracheal injection. Lactate dehydrogenase (LDH), acid phosphatase (AP), protein and phospholipid were determined in cellfree bronchoalveolar lavage (BAL) and lung tissue. The lungs and regional lymph nodes were processed histologically. Lung toxicity of the samples collected during hard metal production varied. Samples containing considerable amount of cobalt dissolved upon acid treatment were found to induce inflammation. It has been established that the biological effect of samples of identical composition is changed by heat treatment and pre-sintering. Our examinations seem to prove that cobalt plays a prominent role in the development of pathological alterations. |
| Databáze: | OpenAIRE |
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