Hyaluronic acid in hydrophilic contact lenses: Spectroscopic investigation of the content and release in solution
| Autor: | Matteo Fagnola, Marco Paolo Pagani, Antonio Papagni, Silvia Tavazzi, Silvio Maffioletti |
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| Přispěvatelé: | Fagnola, M, Pagani, M, Maffioletti, S, Tavazzi, S, Papagni, A |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Hyaluronic acid
Analytical chemistry Sodium Chloride Mass Spectrometry law.invention Diffusion chemistry.chemical_compound Ultraviolet visible spectroscopy Adsorption law Materials Testing Contact lens material CHIM/06 - CHIMICA ORGANICA medicine FIS/03 - FISICA DELLA MATERIA Cationic polymerization Water Blisters General Medicine Contact Lenses Hydrophilic Bio-analytical method UV–vis spectroscopy Solutions Lens (optics) Contact lens Ophthalmology chemistry Chemical engineering Current technology Contact Lens Solutions medicine.symptom Hydrophobic and Hydrophilic Interactions Optometry |
| Popis: | Two experimental spectroscopic methods for the determination of the content of hyaluronic acid in solution are provided based on the formation of complexes between the hyaluronic acid and cationic dyes with sensitivity down to concentrations of either 0.25 or 2.5 microg/ml. These techniques were applied to commercial hydrophilic contact lenses and allowed (i) distinguishing among contact lenses either loaded or non-loaded with hyaluronic acid, (ii) determining, for the loaded ones, the content of hyaluronic acid, (iii) evaluating the release of hyaluronic acid by the lens in solution, and (iv) determining the role of the hyaluronic acid in preventing the adsorption and the successive release by the contact lens of other components which can be present, for example, in the conservation solutions and/or in the blisters of the lenses. The results represent new physical chemistry insights for the field of contact lenses with impact on the advancement of current technology. |
| Databáze: | OpenAIRE |
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