Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007
| Autor: | Yibin Zhuang, Wang Liping, Yi Wang, Cuixian Zhang, Weiming Zhu, Fandong Kong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Circular dichroism
Stereochemistry Pharmaceutical Science Antineoplastic Agents HL-60 Cells Crystallography X-Ray Penicillium sp Streptomyces Inhibitory Concentration 50 chemistry.chemical_compound Phenols Cell Line Tumor Drug Discovery Humans Cytotoxic T cell Cytotoxicity Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 Biological Products biology secondary metabolites Communication Circular Dichroism Penicillium Streptomyces fradiae biology.organism_classification Coculture Techniques chemistry lcsh:Biology (General) Cell culture Polyketides co-cultivation cytotoxicity |
| Zdroj: | Marine Drugs, Vol 12, Iss 4, Pp 2079-2088 (2014) Marine Drugs |
| ISSN: | 1660-3397 |
| Popis: | Penicillium sp. WC-29-5 was co-cultured with Streptomyces fradiae 007 to produce five natural products (1–3, 4a and 4b) that were isolated and characterized by spectroscopic analysis. Interestingly, these compounds were found to be different from those produced in discrete fungal and bacterial controls. Among these compounds, the absolute configurations of compounds 4a and 4b were determined for the first time by X-ray single crystal diffraction experiments and electronic circular dichroism (ECD) calculations. An evaluation of the cytotoxic activities of these compounds revealed that 4b was moderately cytotoxic towards HL-60 and H1975 tumor cells with IC50 values of 3.73 and 5.73 µM, respectively, whereas compound 4a was only moderately cytotoxic towards H1975 cells with an IC50 value of 3.97 µM. |
| Databáze: | OpenAIRE |
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