Ultrasonography of the pancreas, as a function index, in children with beta-thalassemia
| Autor: | H. Nounopoulos, Ioannidou D, Papadogiannis M, C. S. Bartsocas, Karpathios T, A. Bouloukos, Katsikari M, M. Theochari |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Hemosiderosis Gastroenterology Endocrinology Diabetes mellitus Internal medicine Statistical significance medicine Endocrine system Humans Pancreas Ultrasonography business.industry General surgery Insulin Ultrasound beta-Thalassemia Trypsin medicine.disease medicine.anatomical_structure Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 13(3) |
| ISSN: | 0334-018X |
| Popis: | Increased echogenicity of the pancreas, due to hemosiderosis, is a frequent laboratory finding in children and adolescents with beta-thalassemia. The aim of this study was to investigate whether increased echogenicity of the pancreas is associated with dysfunction. The ultrasonic image of the pancreas was examined in 34 children aged 12+/-3.8 years old and was compared to the endocrine and exocrine functioning of the gland. Oral glucose tolerance test (OGTT) was performed with simultaneous measurement of insulin and serum trypsin. Twenty-six of the 34 patients (76.5%) presented increased echogenicity, while 8 (23.5%) had a normal ultrasonic pancreatic image. 77% of the patients with increased echogenicity had abnormal OGTT, 46%, with subnormal or increased insulin values, and 32.5% manifested low levels of trypsin. Among the patients with normal ultrasound, 25% had abnormal OGTT and 37.5% abnormal insulin values. Statistical analysis with Student's t-test revealed that patients with increased echogenicity had significantly higher glucose values on OGTT at 60: 7.6 +/- 1.8 mmol/l (137.3 +/- 33.7 mg/dl) as compared to the patients with normal ultrasound: 6.1 +/- 1.2 mmol/l (110.75 +/- 21.72 mg/dl) (p |
| Databáze: | OpenAIRE |
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