Frontostriatal White Matter Integrity Relations with 'Cool' and 'Hot' Self-Regulation after Pediatric Traumatic Brain Injury
| Autor: | Weihua Fan, Dana M. DeMaster, Candice A. Alfano, Johanna Bick, Jesse T. Fischer, Paul T. Cirino, Linda Ewing-Cobbs |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Dorsum Adolescent Traumatic brain injury Neuropsychological Tests Self-Control White matter Executive Function Brain Injuries Traumatic Humans Medicine Attention Child business.industry Original Articles medicine.disease White Matter Frontal Lobe Diffusion Tensor Imaging medicine.anatomical_structure nervous system Diffusion tensor tractography Female Neurology (clinical) business Neuroscience |
| Zdroj: | J Neurotrauma |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | Traumatic brain injury (TBI) produces microstructural damage to white matter pathways connecting neural structures in pre-frontal and striatal regions involved in self-regulation (SR). Dorsal and ventral frontostriatal pathways have been linked to cognitive (“cool”) and emotional (“hot”) SR, respectively. We evaluated the relation of frontostriatal pathway fractional anisotropy (FA) 2 months post-TBI on cool and hot SR assessed 7 months post-TBI. Participants were 8–15 years of age, including children with uncomplicated mild TBI (mTBI; n = 24), more severe TBI (complicated-mild, moderate, severe [cms]TBI; n = 60), and typically developing (TD) children (n = 55). Diffusion tensor tractography was used to map frontostriatal pathways. Cool SR included focused and sustained attention performance, and parent-reported attention, whereas hot SR included risk-taking performance and parent-reported emotional control. Multivariate general linear models showed that children with cmsTBI had greater parent-reported cool and hot SR difficulties and lower dorsal and ventral FA than TD children. Focused attention, risk taking, and emotional control correlated with FA of specific dorsal and ventral pathways; however, only the effect of TBI on focused attention was mediated by integrity of dorsal pathways. Results suggest that frontostriatal FA may serve as a biomarker of risk for SR difficulties or to assess response to interventions targeting SR in pediatric TBI and in broader neurodevelopmental populations. |
| Databáze: | OpenAIRE |
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