Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q10levels in ICR mice
| Autor: | Shyh Hsiang Lin, Hui Ting Yang, Shih Yi Huang, Hsin Ju Chou |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Ubiquinone Ratón Coenzymes Medicine (miscellaneous) Cofactor Mice chemistry.chemical_compound Ascomycota Internal medicine medicine Red yeast rice Animals Monascus purpureus Lovastatin Coenzyme Q10 Biological Products Mice Inbred ICR Kidney Nutrition and Dietetics biology Myocardium food and beverages biology.organism_classification Endocrinology medicine.anatomical_structure Liver chemistry Biochemistry Coenzyme Q – cytochrome c reductase Dietary Supplements biology.protein medicine.drug |
| Zdroj: | British Journal of Nutrition. 93:131-135 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1079/bjn20041285 |
| Popis: | In this study, we attempted to evaluate the effect of administration of a high quantity of red yeast rice on coenzyme Q10(CoQ10) synthesis in the tissues of ICR mice. Eighty-eight adult male ICR mice were housed and divided into control and experimental groups for red yeast rice treatment. Animals were gavaged with a low (1 g/kg body weight) or a high dose (5 g/kg body weight, approximately five times the typical recommended human dose) of red yeast rice dissolved in soyabean oil. After gavagement, animals of the control group were immediately killed; mice of the experimental groups (eight for each subgroup) were killed at different time intervals of 0·5, 1, 1·5, 4 and 24 h. The liver, heart and kidney were taken for analysis of monacolin K (liver only) and CoQ10analysis. Liver and heart CoQ10levels declined dramatically in both groups administered red yeast rice, especially in the high-dose group, within 30 min. After 24 h, the levels of hepatic and cardiac CoQ10were still reduced. A similar trend was also observed in the heart, but the inhibitory effect began after 90 min. The higher dose of red yeast rice presented a greater suppressive effect than did the lower dose on tissue CoQ10levels. In conclusion, acute red yeast rice gavage suppressed hepatic and cardiac CoQ10levels in rodents; furthermore, the inhibitory effect was responsive to the doses administered. |
| Databáze: | OpenAIRE |
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