A comparative study on the prophylactic effects of paracetamol and dexmedetomidine for controlling hemodynamics during surgery and postoperative pain in patients with laparoscopic cholecystectomy
| Autor: | Gholamreza Noori, Taha Hojati Ashrafi, Siamak Rakei, Afsaneh Norouzi, Alireza Kamali |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Mean arterial pressure medicine.medical_specialty Adolescent paracetamol Visual analogue scale medicine.medical_treatment Hemodynamics Blood Pressure Preoperative care Young Adult 03 medical and health sciences 0302 clinical medicine Heart Rate 030202 anesthesiology Preoperative Care Humans Medicine 030212 general & internal medicine Elective surgery Dexmedetomidine laparoscopic cholecystectomy Acetaminophen Aged Pain Postoperative business.industry dexmedetomidine perioperative vital sign Clinical Trial/Experimental Study General Medicine Analgesics Non-Narcotic Middle Aged Surgery Blood pressure Cholecystectomy Laparoscopic Female Cholecystectomy postoperative pain business Research Article medicine.drug |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000013330 |
| Popis: | Background: Today, the ever-expanding technology is inevitably shadowing on all aspects of human life. This study was aimed to compare the prophylactic effects of paracetamol and dexmedetomidine for controlling hemodynamics during surgery and postoperative pain. Methods: The study population consisted of 132 patients aged 18 to 70 years and from both genders, who were candidates for emergency cholecystectomy or elective surgery. Group A consisted of 66 patients who received dexmedetomidine, and Group B included 66 patients with paracetamol administration. The amount of postoperative pain was measured on the basis of visual analog scale, arterial blood pressure, as well as heart rate at recovery and 4, 12, and 24 hours after surgery. Results: The mean age in the 2 groups was similar and almost equal to 52 years; there was no difference in the sex ratios in both groups (P > .05). Pain score in the paracetamol group was significantly lower than that in the dexmedetomidine group (P = .04); nevertheless, there were no group differences in the mean scores of pain during these hours (P > .05). The median opioid use in 24 hours after operation in the paracetamol group was lower when compared with that in the dexmedetomidine group, and the mean duration of analgesia in the paracetamol group was higher when comparing with dexmedetomidine group. Furthermore, in both groups, mean arterial pressure and preoperative PR interval were similar at various times. Conclusion: The findings demonstrated that both regimens of drugs can control the hemodynamic status of patients during laparoscopic cholecystectomy, which provides effective postoperative analgesia for pain management. |
| Databáze: | OpenAIRE |
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