TRPC Channels and Parkinson's Disease
| Autor: | Brij B. Singh, Pramod Sukumaran, Anne Schaar, Senthil Selvaraj, Yuyang Sun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Parkinson's disease Substantia nigra Biology Article 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine medicine Animals Humans TRPC Calcium signaling TRPC Cation Channels Pars compacta Calcium channel Dopaminergic Neurons Brain Parkinson Disease medicine.disease 030104 developmental biology nervous system Calcium Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9789402410860 |
| ISSN: | 0065-2598 |
| Popis: | Parkinson disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson disease, however almost all of them are directly or indirectly dependent on Ca2+ signaling. Importantly, though disturbances in Ca2+ homeostasis have been implicated in Parkinson’s disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identified as a new class of calcium channels and it could be anticipated that these channels could play a major role in neurodegenerative diseases, especially in PD. Thus, in this chapter we have entirely focused our attention on TRPC channels and elucidating its role in PD. |
| Databáze: | OpenAIRE |
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