Drinking water application of Denagard® Tiamulin for control of Brachyspira pilosicoli infection of laying poultry
| Autor: | Sandrine P. Claus, Paul Davies, Martin J. Woodward, Roberto M. La Ragione, Gavin Thompson, Caroline I. Le Roy, Luke J. Mappley |
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| Rok vydání: | 2015 |
| Předmět: |
Brachyspira
Veterinary medicine Tiamulin Brachyspira pilosicoli Ileum chemistry.chemical_compound medicine Animals Eggshell Poultry Diseases Dose-Response Relationship Drug General Veterinary biology Drinking Water Broiler biology.organism_classification Anti-Bacterial Agents medicine.anatomical_structure chemistry Female Flock Diterpenes medicine.symptom Gram-Negative Bacterial Infections Chickens Weight gain |
| Zdroj: | Research in Veterinary Science. 103:87-95 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2015.09.015 |
| Popis: | Avian intestinal spirochaetosis (AIS) caused by Brachyspira spp., and notably Brachyspira pilosicoli, is common in layer flocks and reportedly of increasing incidence in broilers and broiler breeders. Disease manifests as diarrhoea, increased feed consumption, reduced growth rates and occasional mortality in broilers and these signs are shown in layers also associated with a delayed onset of lay, reduced egg weights, faecal staining of eggshells and non-productive ovaries. Treatment with Denagard® Tiamulin has been used to protect against B. pilosicoli colonisation, persistence and clinical presentation of AIS in commercial layers, but to date there has been no definitive study validating efficacy. Here, we used a poultry model of B. pilosicoli infection of layers to compare the impact of three doses of Denagard® Tiamulin. Four groups of thirty 17 week old commercial pre-lay birds were all challenged with B. pilosicoli strain B2904 with three oral doses two days apart. All birds were colonised within 2 days after the final oral challenge and mild onset of clinical signs were observed thereafter. A fifth group that was unchallenged and untreated was also included for comparison as healthy birds. Five days after the final oral Brachypira challenge three groups were given Denagard® Tiamulin in drinking water made up following the manufacturer's recommendations with doses verified as 58.7 ppm, 113 ppm and 225 ppm. Weight gain body condition and the level of diarrhoea of birds infected with B. pilosicoli were improved and shedding of the organism reduced significantly (p=0.001) following treatment with Denagard® Tiamulin irrespective of dose given. The level and duration of colonisation of organs of birds infected with B. pilosicoli was also reduced. Confirming previous findings we showed that the ileum, caeca, colon, and both liver and spleen were colonised and here we demonstrated that treatment with Denagard® Tiamulin resulted in significant reduction in the numbers of Brachyspira found in each of these sites and dramatic reduction in faecal shedding (p |
| Databáze: | OpenAIRE |
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